Narcolepsy is a rare brain disorder that reflects a selective loss or dysfunction of orexin (also
known as hypocretin) neurons of the lateral hypothalamus. Narcolepsy type 1 (NT1) is …

Background and aim Narcolepsy is an uncommon hypothalamic disorder of presumed
autoimmune origin that usually requires lifelong treatment. This paper aims to provide …

Narcolepsy is a chronic sleep disorder that has a typical onset in adolescence and is
characterized by excessive daytime sleepiness, which can have severe consequences for …

Abstract Modafinil (2-[(Diphenylmethyl) sulfinyl] acetamide, Provigil) is an FDA-approved
medication with wake-promoting properties. Pre-clinical studies of modafinil suggest a …

Psychostimulants such as cocaine have been used as performance enhancers throughout
recorded history. Although psychostimulants are commonly prescribed to improve attention …

Narcolepsy, a chronic neurologic condition resulting from dysregulation of the sleep–wake
cycle, usually has an onset at an early age. However, a long delay until diagnosis has been …

Objective Solriamfetol (JZP‐110) is a selective dopamine and norepinephrine reuptake
inhibitor with wake‐promoting effects. This phase 3 study (NCT02348593) evaluated the …

Rationale. Modafinil, a novel wake-promoting agent, has been shown to have a similar
clinical profile to that of conventional stimulants such as methylphenidate. We were therefore …

Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the
central nervous system, characterized by the accumulation of numerous neurological …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …