DNA and RNA can fold into a variety of alternative conformations. In recent years, a
particular nucleic acid structure was discussed to play a role in malignant transformation and …

The effectiveness of many anticancer drugs depends on the creation of specific metabolites
that may alter their therapeutic or toxic properties. One significant route of biotransformation …

This review summarized the current breakthroughs in the chemistry of acridines as anti-
cancer agents, including new structural and biologically active acridine attributes. Acridine …

Colorectal Cancer (CRC) is one of the leading causes of cancer-related deaths worldwide.
Despite the notable advances achieved over the last few decades, CRC remains a hard-to …

Targeted drug delivery by nanocarriers molecules can increase the efficiency of cancer
treatment. One of the targeting ligands is folic acid (FA), which has a high affinity for the folic …

Selective therapy and controlled drug release at an intracellular level remain key challenges
for effective cancer treatment. Here, we employed folic acid (FA) as a self-navigating …

Nanotechnology-based drug delivery provides a promising area for improving the efficacy of
cancer treatments. Therefore, we investigate the potential of using quantum dots (QDs) as …

The clinical effectiveness of the available anticancer drugs has been reduced due to the
development of drug resistance and serious adverse effects, which have restricted …

Genomic instability and inflammation are considered to be two enabling characteristics that
support cancer development and progression. G-quadruplex structure is a key element that …

Members of a novel class of anticancer compounds, exhibiting high antitumor activity, ie the
unsymmetrical bisacridines (UAs), consist of two heteroaromatic ring systems. One of the …