Transposable elements (TEs) promote genetic innovation but also threaten genome stability.
Despite multiple layers of host defence, TEs actively shape mammalian-specific …

For many years, transcription factor Sp1 was viewed as a basal transcription factor and
relegated to a role in the regulation of so‐called housekeeping genes. Identification of Sp1's …

Abstract Sp1 (specificity protein 1) is a well-known member of a family of transcription factors
that also includes Sp2, Sp3 and Sp4, which are implicated in an ample variety of essential …

Sp1 belongs to the 26 member strong Sp/KLF family of transcription factors. It is a paradigm
for a ubiquitously expressed transcription factor and is involved in regulating the expression …

Sp1 and Sp3 are transcription factors expressed in all mammalian cells. These factors are
involved in regulating the transcriptional activity of genes implicated in most cellular …

Trophoblasts, important functional cells in the placenta, play a critical role in maintaining
placental function. The heterogeneity of trophoblasts has been reported, but little is known …

Trophoblast giant cells (TGCs) are the first cell type to terminally differentiate during
embryogenesis and are of vital importance for implantation and modulation of post …

Angiogenesis is a critical pathophysiological process involved in organ growth and various
diseases. Transcription factors Sp1/Sp3 are necessary for fetal development and tumor …

The X-linked DEAD-box RNA helicase DDX3 (DDX3X) is a multifunctional protein that has
been implicated in gene regulation, cell cycle control, apoptosis, and tumorigenesis …

Endothelial dysfunction represents a major cardiovascular risk factor for hypertension. Sp1
and Sp3 belong to the specificity protein and Krüppel-like transcription factor families. They …