At implantation, the embryo expresses paternally derived alloantigens and evokes
inflammation that can threaten reproductive success. To ensure a robust placenta and …

Natural killer (NK) cells constitute our bodies' frontline defense system, guarding against
tumors and launching attacks against infections. The activities of NK cells are regulated by …

Labeled problem Embryo implantation remains the main limiting factor in assisted
reproductive medicine (20% success rate). Methods of study An endometrial immune …

Immune cells are essential for endometrial receptivity to embryo implantation and early
placental development. They exert tissue-remodeling and immune regulatory roles—acting …

Immune cells in the placental bed are important for adequate development of the placental
bed. The most prominent immune cells in the placental bed early in pregnancy are uterine …

T regulatory (Treg) cells are essential mediators of the maternal immune adaptation
necessary for embryo implantation. In mice, insufficient Treg cell activity results in …

The kynurenine pathway (KP) is highly regulated in the immune system, where it promotes
immunosuppression in response to infection or inflammation. Indoleamine 2, 3-dioxygenase …

Successful pregnancy and long-term, post-natal maternal and offspring cardiac, vascular
and metabolic health require key maternal cardiovascular adaptations over gestation. Within …

Inflammation is a central feature and is implicated as a causal factor in preeclampsia and
other hypertensive disorders of pregnancy. Inflammatory mediators and leukocytes, which …

BACKGROUND After recognition of its pivotal contribution to fetomaternal tolerance, the
study of galectin-1 (gal-1) functions in the context of pregnancy became an attractive topic in …