Heterotrimeric G proteins have a crucial role as molecular switches in signal transduction
pathways mediated by G-protein-coupled receptors. Extracellular stimuli activate these …

This review is concerned with the structures and mechanisms of a superfamily of regulatory
GTP hydrolases (G proteins). G proteins include Ras and its close homologs, translation …

The crystallographic structure of the G protein heterotrimer Gi,,(GDP) P, y2 (at 2.3 8) reveals
two nonoverlapping regions of contact between a and p, an extended interface between p …

In multicellular organisms from Caenorhabditis elegans to Homo sapiens, the maintenance
of homeostasis is dependent on the continual flow and processing of information through a …

Heterotrimeric G-proteins are intracellular partners of G-protein-coupled receptors (GPCRs).
GPCRs act on inactive Gα· GDP/Gβγ heterotrimers to promote GDP release and GTP …

▪ Abstract Guanine nucleotide binding (G) proteins relay extracellular signals encoded in
light, small molecules, peptides, and proteins to activate or inhibit intracellular enzymes and …

Hundreds of chemical and physical signals constantly bombard the surface of all cells.
Some of these do not enter the cell but, instead, bind to receptors at the cell surface and …

G protein-coupled receptors (GPCRs) are of considerable interest due to their importance in
a wide range of physiological functions and in a large number of Food and Drug …

G βγ subunits from heterotrimeric G proteins perform a vast array of functions in cells with
respect to signaling, often independently as well as in concert with G α subunits. However …

Retinal photoreceptors use the heterotrimeric G protein transducin to couple rhodopsin to a
biochemical cascade that underlies the electrical photoresponse. Several isoforms of each …