Inflammation is a key driver in many pathological conditions such as allergy, cancer,
Alzheimer's disease, and many others, and the current state of available drugs prompted …

Histone deacetylase inhibitors (HDACi) comprise structurally diverse compounds that are a
group of targeted anticancer agents. The first of these new HDACi, vorinostat …

Activation of the KEAP1-NRF2 signaling pathway is an adaptive response to environmental
and endogenous stresses and serves to render animals resistant to chemical …

Nonspecific histone deacetylase (HDAC) inhibition has been shown to facilitate the
extinction of drug-seeking behavior in a manner resistant to reinstatement. A key open …

Constitutively activated NF-κB occurs in many inflammatory and tumor tissues. Does it
interfere with anti-inflammatory or anti-tumor signaling pathway? Here, we report that NF-κB …

BACKGROUND The placenta is of utmost importance for intrauterine fetal development and
growth. Deregulation of placentation can lead to adverse outcomes for both mother and …

In this review, we comprehensively present the function of epigenetic regulations in normal
placental development as well as in a prominent disease of placental origin, preeclampsia …

In humans, cell fusion is restricted to only a few cell types under normal conditions. In the
placenta, cell fusion is a critical process for generating syncytiotrophoblast: the giant …

Preeclampsia (PE), the leading cause of maternal and fetal morbidity and mortality, is
associated with poor fetal growth, intrauterine growth restriction (IUGR) and low birth weight …

Epigenetics is focused on understanding the control of gene expression beyond what is
encoded in the sequence of DNA. Central to growing interest in the field is the hope that …