Homeostasis of multicellular organisms is critically dependent on the correct interpretation of
the plethora of signals which cells are exposed to during their lifespan. Various soluble …

In multicellular organisms, communication between individual cells is essential for the
regulation and coordination of complex cellular processes such as growth, differentiation …

Overexpression of the receptor tyrosine kinase (RTK) erbB2 (also designated neu or HER2)
was implicated in causing a variety of human cancers, including mammary and ovarian …

This review considers the biology of the type 1 growth factor receptor family which is
increasingly recognised as important in the control of normal cell proliferation and in the …

BACKGROUND: Alterations of the HER2 (also known as erbB-2 or neu) proto-oncogene
have been implicated in the carcinogenesis and prognosis of breast cancer. A …

Barros FFT, Powe DG, Ellis IO & Green AR (2010) Histopathology56, 560–572
Understanding the HER family in breast cancer: interaction with ligands, dimerization and …

The sequencing of the human genome has allowed the identification of thousands of gene
polymorphisms, most often single nucleotide polymorphims (SNP), which may play an …

The aims of this study were to explore the relationship between clinical outcome and HER-2
protein expression in dogs with malignant mammary tumours after surgery and to determine …

Background: Trastuzumab has no major side-effects except the potential for cardiac toxicity.
The main objective of this study was to evaluate the association between trastuzumab …

We have investigated c-erbB-2 protein expression in a large cohort of well-characterized
colorectal tumours, and in a subset of lymph node metastases. We have also evaluated a …