Physiology and pathophysiology of human airway mucus

DB Hill, B Button, M Rubinstein… - Physiological …, 2022 - journals.physiology.org
The mucus clearance system is the dominant mechanical host defense system of the human
lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid …

First contact: the role of respiratory cilia in host-pathogen interactions in the airways

LE Kuek, RJ Lee - … Journal of Physiology-Lung Cellular and …, 2020 - journals.physiology.org
Respiratory cilia are the driving force of the mucociliary escalator, working in conjunction
with secreted airway mucus to clear inhaled debris and pathogens from the conducting …

A periciliary brush promotes the lung health by separating the mucus layer from airway epithelia

B Button, LH Cai, C Ehre, M Kesimer, DB Hill… - Science, 2012 - science.org
Mucus clearance is the primary defense mechanism that protects airways from inhaled
infectious and toxic agents. In the current gel-on-liquid mucus clearance model, a mucus gel …

The multiscale physics of cilia and flagella

W Gilpin, MS Bull, M Prakash - Nature Reviews Physics, 2020 - nature.com
Cilia and flagella are fundamental units of motion in cellular biology. These beating, hair-like
organelles share a common basic structure but maintain widely varying functions in systems …

Single-molecule force stability of the SARS-CoV-2–ACE2 interface in variants-of-concern

MS Bauer, S Gruber, A Hausch, MCR Melo… - Nature …, 2024 - nature.com
Mutations in SARS-CoV-2 have shown effective evasion of population immunity and
increased affinity to the cellular receptor angiotensin-converting enzyme 2 (ACE2) …

Emergent complexity of the cytoskeleton: from single filaments to tissue

F Huber, J Schnauß, S Rönicke, P Rauch… - Advances in …, 2013 - Taylor & Francis
Despite their overwhelming complexity, living cells display a high degree of internal
mechanical and functional organization which can largely be attributed to the intracellular …

Fabrication and manipulation of ciliary microrobots with non-reciprocal magnetic actuation

S Kim, S Lee, J Lee, BJ Nelson, L Zhang, H Choi - Scientific reports, 2016 - nature.com
Magnetically actuated ciliary microrobots were designed, fabricated and manipulated to
mimic cilia-based microorganisms such as paramecia. Full three-dimensional (3D) …

Modeling of magnetic cilia carpet robots using discrete differential geometry formulation

W Huang, M Liu, KJ Hsia - Extreme Mechanics Letters, 2023 - Elsevier
Cilia broadly exist in a wide range of living systems. The metachronal waves generated by
arrays of beating cilia are essential for realizing complex biological functions, such as …

Origin and role of the cerebrospinal fluid bidirectional flow in the central canal

O Thouvenin, L Keiser, Y Cantaut-Belarif… - Elife, 2020 - elifesciences.org
Circulation of the cerebrospinal fluid (CSF) contributes to body axis formation and brain
development. Here, we investigated the unexplained origins of the CSF flow bidirectionality …

[HTML][HTML] Breathing on chip: Dynamic flow and stretch accelerate mucociliary maturation of airway epithelium in vitro

JC Nawroth, D Roth, A van Schadewijk, A Ravi… - Materials Today Bio, 2023 - Elsevier
Human lung function is intricately linked to blood flow and breathing cycles, but it remains
unknown how these dynamic cues shape human airway epithelial biology. Here we report a …