Traumatic brain injuries: pathophysiology and potential therapeutic targets

SY Ng, AYW Lee - Frontiers in cellular neuroscience, 2019 - frontiersin.org
Traumatic brain injury (TBI) remains one of the leading causes of morbidity and mortality
amongst civilians and military personnel globally. Despite advances in our knowledge of the …

Traumatic brain injury: mechanistic insight on pathophysiology and potential therapeutic targets

K Thapa, H Khan, TG Singh, A Kaur - Journal of Molecular Neuroscience, 2021 - Springer
Traumatic brain injury (TBI) causes brain damage, which involves primary and secondary
injury mechanisms. Primary injury causes local brain damage, while secondary damage …

The far-reaching scope of neuroinflammation after traumatic brain injury

DW Simon, MJ McGeachy, H Bayır, RSB Clark… - Nature Reviews …, 2017 - nature.com
The'silent epidemic'of traumatic brain injury (TBI) has been placed in the spotlight as a result
of clinical investigations and popular press coverage of athletes and veterans with single or …

Neuroinflammation: the devil is in the details

DJ DiSabato, N Quan, JP Godbout - Journal of neurochemistry, 2016 - Wiley Online Library
There is significant interest in understanding inflammatory responses within the brain and
spinal cord. Inflammatory responses that are centralized within the brain and spinal cord are …

Microglial activation in traumatic brain injury

CK Donat, G Scott, SM Gentleman… - Frontiers in aging …, 2017 - frontiersin.org
Microglia have a variety of functions in the brain, including synaptic pruning, CNS repair and
mediating the immune response against peripheral infection. Microglia rapidly become …

Revisiting traumatic brain injury: from molecular mechanisms to therapeutic interventions

A Jarrahi, M Braun, M Ahluwalia, RV Gupta, M Wilson… - Biomedicines, 2020 - mdpi.com
Studying the complex molecular mechanisms involved in traumatic brain injury (TBI) is
crucial for developing new therapies for TBI. Current treatments for TBI are primarily focused …

Neuroinflammatory responses to traumatic brain injury: etiology, clinical consequences, and therapeutic opportunities

D Lozano, GS Gonzales-Portillo, S Acosta… - Neuropsychiatric …, 2015 - Taylor & Francis
Traumatic brain injury (TBI) is a serious public health problem accounting for 1.4 million
emergency room visits by US citizens each year. Although TBI has been traditionally …

Priming the inflammatory pump of the CNS after traumatic brain injury

KG Witcher, DS Eiferman, JP Godbout - Trends in neurosciences, 2015 - cell.com
Traumatic brain injury (TBI) can lead to secondary neuropsychiatric problems that develop
and persist years after injury. Mounting evidence indicates that neuroinflammatory …

Pharmacotherapy of traumatic brain injury: state of the science and the road forward: report of the Department of Defense Neurotrauma Pharmacology Workgroup

R Diaz-Arrastia, PM Kochanek, P Bergold… - Journal of …, 2014 - liebertpub.com
Despite substantial investments by government, philanthropic, and commercial sources over
the past several decades, traumatic brain injury (TBI) remains an unmet medical need and a …

Neuroinflammation in traumatic brain injury: a chronic response to an acute injury

SJ Schimmel, S Acosta, D Lozano - Brain circulation, 2017 - journals.lww.com
Abstract Every year, approximately 1.4 million US citizens visit emergency rooms for
traumatic brain injuries. Formerly known as an acute injury, chronic neurodegenerative …