Neutrophils are the first responders to infection and inflammation and are thus a critical
component of innate immune defense. Understanding the behavior of neutrophils as they …

Over the past millennia, life expectancy has drastically increased. While a mere 25 years
during Bronze and Iron ages, life expectancy in many European countries and in Japan is …

Osteoporosis is a skeletal system disease characterized by low bone mass and altered bone
microarchitecture, with an increased risk of fractures. Classical theories hold that …

Aging affects all tissues and organs. Aging of the immune system results in the severe
disruption of its functions, leading to an increased susceptibility to infections, an increase in …

Neutrophils, the most prevalent innate immune cells in humans, have garnered significant
attention in recent years due to their involvement in cancer progression. This comprehensive …

An increasing body of literature supports a role for neutrophils as players in the orchestration
of adaptive immunity. During acute and chronic inflammatory conditions, neutrophils rapidly …

Ageing is a complex biological process associated with increased morbidity and mortality.
Nine classic, interdependent hallmarks of ageing have been proposed involving genetic and …

Immunosenescence is a process associated with aging that leads to dysregulation of cells of
innate and adaptive immunity, which may become dysfunctional. Consequently, older adults …

Neutrophils play a key role in innate immunity. As the dominant circulating phagocyte, they
are rapidly recruited from the bloodstream to sites of infection or injury to internalize and …

Immune cells are rapidly recruited to a site of injury or infection. Although the importance of
phagocytic immune cells in clearing bacteria has long been appreciated, the advent of …