Combination antiretroviral therapy (ART) can block multiple stages of the HIV-1 life cycle to
prevent progression to AIDS in people living with HIV-1. However, owing to the persistence …

HIV infection has a significant impact on the natural history of chronic hepatitis B virus (HBV)
infection, with increased levels of HBV DNA, accelerated progression of liver disease and …

Reversal of HIV-1 latency by small molecules is a potential cure strategy. This approach will
likely require effective drug combinations to achieve high levels of latency reversal. Using …

Combinatory antiretroviral therapy (cART) reduces human immunodeficiency virus type 1
(HIV-1) replication but is not curative because cART interruption almost invariably leads to a …

One of the most explored therapeutic approaches aimed at eradicating HIV-1 reservoirs is
the “shock and kill” strategy which is based on HIV-1 reactivation in latently-infected cells …

The implementation of antiretroviral therapy 23 years ago has rendered HIV infection
clinically manageable. However, the disease remains incurable, since it establishes latent …

BACKGROUND A central challenge to emerging efforts to cure HIV infection is the
persistence of quiescent but replication-competent proviral genomes in resting CD4+ T …

The presence of persistent, latent HIV reservoirs in CD4+ T cells obstructs current efforts to
cure infection. The so-called kick-and-kill paradigm proposes to purge these reservoirs by …

Antiretroviral therapy (ART) has rendered HIV-1 infection a treatable illness; however, ART
is not curative owing to the persistence of replication-competent, latent proviruses in long …

Antiretroviral therapy can suppress HIV replication to undetectable levels but does not
eliminate latent HIV, thus necessitating lifelong therapy. Recent efforts to target this …