SOCS are a family of negative inhibitors of the molecular cascades induced by cytokines,
growth factors and hormones. At molecular level, SOCS proteins inhibit the kinase activity of …

Autism spectrum disorder (ASD1) is a behaviorally defined syndrome encompassing a
markedly heterogeneous patient population. Many ASD subjects fail to respond to the 1st …

Juvenile idiopathic arthritis (JIA) is the most prevalent pediatric rheumatic disease. While
disease‐modifying antirheumatic drugs (DMARDs), especially biologics, have greatly …

Neutrophils, the most abundant type of granulocyte, are widely recognized as one of the
pivotal contributors to the acute inflammatory response. Initially, neutrophils were …

Background The limited therapeutic options and inconsistent treatment efficacy of Intestinal
Behçet's disease complicate its management, with the absence of standardized guidelines …

Abstract Background and Objective Upadacitinib is indicated for diseases affecting persons
of childbearing potential including rheumatoid arthritis, psoriatic arthritis, axial …

Purpose This study aims to characterize the pharmacokinetics, safety, tolerability, and
exploratory efficacy of upadacitinib, an oral Janus kinase inhibitor approved for treating …

Psoriasis is a highly prevalent dermatological disease associated with an increased
systemic inflammatory response. In addition, joint involvement is also present in around 20 …

Introduction Pruritus, particularly in its chronic form, often imposes significant suffering and
reductions in patients' quality of life. The pathophysiology of itch is varied depending on …

Recent advancements in the treatment landscape of ulcerative colitis (UC) have ushered in
a new era of possibilities, particularly with the introduction of Janus kinase (JAK)-signal …