In the past decade, significant progress has been made in complex disease research across
multiple omics layers from genome, transcriptome and proteome to metabolome. There is an …

Network Medicine applies network science approaches to investigate disease
pathogenesis. Many different analytical methods have been used to infer relevant molecular …

Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as
BRCA1, and many common, mostly non-coding variants. However, much of the genetic …

The genetic architecture of common traits, including the number, frequency, and effect sizes
of inherited variants that contribute to individual risk, has been long debated. Genome-wide …

Most common breast cancer susceptibility variants have been identified through genome-
wide association studies (GWAS) of predominantly estrogen receptor (ER)-positive disease …

Biological entities are involved in intricate and complex interactions, in which uncovering the
biological information from the network concepts are of great significance. Benefiting from …

We performed a genome-wide association study (GWAS) of IgA nephropathy (IgAN), the
most common form of glomerulonephritis, with discovery and follow-up in 20,612 individuals …

Although chronic obstructive pulmonary disease (COPD) risk is strongly influenced by
cigarette smoking, genetic factors are also important determinants of COPD. In addition to …

PERSPECTIVE interplay of signal transduction, transcriptional, post-transcriptional,
metabolic and other regulatory events that determine cell behavior. Even today, entirely new …

The first decade of Genome Wide Association Studies (GWAS) has uncovered a wealth of
disease-associated variants. Two important derivations will be the translation of this …