Lines of evidence coming from many branches of neuroscience indicate that anxiety
disorders arise from a dysfunction in the modulation of brain circuits which regulate …

The role of γ-aminobutyric acid (GABA) as a signal in animals has been documented for
over 60 years. In contrast, evidence that GABA is a signal in plants has only emerged in the …

Cys-loop receptors are membrane-spanning neurotransmitter-gated ion channels that are
responsible for fast excitatory and inhibitory transmission in the peripheral and central …

▪ Abstract Using luminescent lanthanides, instead of conventional fluorophores, as donor
molecules in resonance energy transfer measurements offers many technical advantages …

Neurotransmitter receptor systems have been the focus of intensive pharmacological
research for more than 20 years for basic and applied scientific reasons, but only recently …

New hypotheses and predictions have arisen from recent work revealing atomic-scale or
near-atomic-scale structures of receptors in the 'Cys-loop'superfamily. How general is the …

The major isoform of the γ-aminobutyric acid type A (GABA A) receptor is thought to be
composed of 2α 1, 2β 2, and 1γ 2 subunit (s), which surround the ion pore. Definite evidence …

Neurotransmitters such as acetylcholine and GABA (γ-aminobutyric acid) mediate rapid
synaptic transmission by activating receptors belonging to the gene superfamily of ligand …

1 Wild‐type and mutant α1β2γ2 GABAA receptors were expressed in Xenopus laevis
oocytes and examined using the two‐electrode voltage clamp. 2 Dose–response …

The segmented aspect of the vertebrate body plan first arises through the sequential
formation of somites. The periodicity of somitogenesis is thought to be regulated by a …