The Myotendinous Junction—Form and Function

AL Mackey - Cold Spring Harbor perspectives in biology, 2024 - cshperspectives.cshlp.org
A critical link in the chain of force transmission from muscle fiber cross-bridge to bone is the
interface between muscle and tendon—the myotendinous junction (MTJ). To meet the …

Functional specialisation and coordination of myonuclei

A Korb, S Tajbakhsh, GE Comai - Biological Reviews, 2024 - Wiley Online Library
Myofibres serve as the functional unit for locomotion, with the sarcomere as fundamental
subunit. Running the entire length of this structure are hundreds of myonuclei, located at the …

Lack of skeletal muscle contraction disrupts fibrous tissue morphogenesis in the developing murine knee

TK Tsinman, Y Huang, S Ahmed… - Journal of …, 2023 - Wiley Online Library
Externally applied forces, such as those generated through skeletal muscle contraction, are
important to embryonic joint formation, and their loss can result in gross morphologic defects …

Advances in Tissue Engineering Approaches for Repairing and Rehabilitating the Myotendinous Junction

KA Shama, MA Turner, HB Broadaway… - Current Opinion in …, 2024 - Elsevier
The myotendinous junction (MTJ) acts as a bridge between muscle and tendon; yet its high
stiffness relative to muscle fibers renders the tissue susceptible to injuries due to eccentric …

3D-environment and muscle contraction regulate the heterogeneity of myonuclei

R Nicolas, MA Bonnin, C Blavet, JE de Lima… - Skeletal Muscle, 2024 - Springer
Skeletal muscle formation involves tight interactions between muscle cells and associated
connective tissue fibroblasts. Every muscle displays the same type of organisation, they are …

Supraspinatus Tendon Reconstruction Versus the Bridging Technique in a Rat Model: Histological, Biomechanical, and Functional Outcomes

Y Liao, J Wang, Z Zhou, B Tang, H Li… - … American Journal of …, 2024 - journals.sagepub.com
Background: Massive irreparable rotator cuff tears (MIRCTs) are among the most
challenging shoulder conditions to treat surgically. Supraspinatus tendon reconstruction …

[HTML][HTML] Engineering interfacial tissues: The myotendinous junction

F Snow, C O'Connell, P Yang, M Kita, E Pirogova… - APL …, 2024 - pubs.aip.org
The myotendinous junction (MTJ) is the interface connecting skeletal muscle and tendon
tissues. This specialized region represents the bridge that facilitates the transmission of …

Spatial and mechanical environments regulate the heterogeneity of myonuclei

R Nicolas, MA Bonnin, C Blavet, J Esteves de Lima… - bioRxiv, 2024 - biorxiv.org
Skeletal muscle formation involves tight interactions between muscle cells and associated
connective tissue fibroblasts. Every muscle displays the same type of organisation, they are …

Mechanical Force Works as a Biological Cue in Postnatal Murine Tendon Development

Y Usami, X Jiang, NA Dyment, T Kokubun - bioRxiv, 2023 - biorxiv.org
The musculoskeletal system provides structural stability and coordination to enable
movement. Tendons have the essential role of efficiently transmitting force generated from …

In Situ and In Vivo Roles of Focal Adhesion Kinase in Tendon Development and Mechanotransduction

TP Leahy - 2023 - search.proquest.com
Tendons enable locomotion by transmitting high tensile mechanical forces between muscle
and bone via their dense extracellular matrix (ECM). The application of extrinsic mechanical …