Oxidative stress‐related mechanisms in schizophrenia pathogenesis and new treatment perspectives

EA Ermakov, EM Dmitrieva… - Oxidative Medicine …, 2021 - Wiley Online Library
Schizophrenia is recognized to be a highly heterogeneous disease at various levels, from
genetics to clinical manifestations and treatment sensitivity. This heterogeneity is also …

Riding the tiger–physiological and pathological effects of superoxide and hydrogen peroxide generated in the mitochondrial matrix

MD Brand - Critical reviews in biochemistry and molecular biology, 2020 - Taylor & Francis
Elevated mitochondrial matrix superoxide and/or hydrogen peroxide concentrations drive a
wide range of physiological responses and pathologies. Concentrations of superoxide and …

The role of pharmacogenomics in adverse drug reactions

R Cacabelos, N Cacabelos, JC Carril - Expert Review of Clinical …, 2019 - Taylor & Francis
ABSTRACT Introduction: Adverse drug reactions (ADRs) are a major health concern
worldwide. There are multiple causes of ADRs, some of which are preventable …

New insights into the mechanism of drug-induced dyskinesia

AJM Loonen, SA Ivanova - CNS spectrums, 2013 - cambridge.org
Dyskinesia is an extrapyramidal movement disorder characterized by involuntary, repetitive,
irregular motions that affect the mouth and face and/or the limbs and trunk. Tardive …

The contribution of oxidative stress to drug-induced organ toxicity and its detection in vitro and in vivo

CV Pereira, S Nadanaciva, PJ Oliveira… - Expert opinion on drug …, 2012 - Taylor & Francis
Introduction: Nowadays the 'redox hypothesis' is based on the fact that thiol/disulfide couples
such as glutathione (GSH/GSSG), cysteine (Cys/CySS) and thioredoxin ((Trx-(SH) 2/Trx-SS)) …

[HTML][HTML] Putative role of immune reactions in the mechanism of tardive dyskinesia

AJM Loonen - Brain, Behavior, & Immunity-Health, 2023 - Elsevier
The term extrapyramidal disorders is most often used for conditions such as Parkinson's
disease or Huntington's disease, but also refers to a group of extrapyramidal side effects of …

Oxidative stress and tardive dyskinesia: pharmacogenetic evidence

CH Cho, HJ Lee - Progress in Neuro-Psychopharmacology and …, 2013 - Elsevier
Tardive dyskinesia (TD) is a serious adverse effect of long-term antipsychotic use. Because
of genetic susceptibility for developing TD and because it is difficult to predict and prevent its …

Redox processes in neurodegenerative disease involving reactive oxygen species

P Kovacic, R Somanathan - Current neuropharmacology, 2012 - ingentaconnect.com
Much attention has been devoted to neurodegenerative diseases involving redox
processes. This review comprises an update involving redox processes reported in the …

Поиск биомаркеров и разработка фармакогенетических подходов к персонализированной терапии больных шизофренией

СА Иванова, ОЮ Федоренко, ЛП Смирнова… - … вестник психиатрии и …, 2013 - elibrary.ru
В статье представлены предварительные результаты исследований в области
трансляционной психиатрии. Основные направления связаны с поиском биомаркеров …

Pharmacogenetics of tardive dyskinesia: an updated review of the literature

RK Lanning, CC Zai, DJ Müller - Pharmacogenomics, 2016 - Taylor & Francis
Tardive dyskinesia (TD) is a serious and potentially irreversible side effect of long-term
exposure to antipsychotic medication characterized by involuntary trunk, limb and orofacial …