Unrealized targets in the discovery of antibiotics for gram-negative bacterial infections

U Theuretzbacher, B Blasco, M Duffey… - Nature Reviews Drug …, 2023 - nature.com
Advances in areas that include genomics, systems biology, protein structure determination
and artificial intelligence provide new opportunities for target-based antibacterial drug …

An omics perspective on drug target discovery platforms

J Paananen, V Fortino - Briefings in bioinformatics, 2020 - academic.oup.com
The drug discovery process starts with identification of a disease-modifying target. This
critical step traditionally begins with manual investigation of scientific literature and …

[HTML][HTML] Advancing engineered approaches for sustainable wound regeneration and repair: Harnessing the potential of green synthesized silver nanoparticles

J Nandhini, E Karthikeyan, EE Rani, VS Karthikha… - Engineered …, 2024 - Elsevier
Wound healing is a crucial biological process for tissue repair and regeneration, preventing
infections and complications. There's been a growing interest in exploring sustainable …

Inverted perovskite/silicon V-shaped tandem solar cells with 27.6% efficiency via self-assembled monolayer-modified nickel oxide layer

L Zheng, Y Xuan, J Wang, S Bao, X Liu… - Journal of Materials …, 2022 - pubs.rsc.org
A novel inverted perovskite/silicon V-shaped tandem solar cell is proposed based on an
elaborate design of photon matching and management, in which the underutilized above …

Potential therapeutic targets of Klebsiella pneumoniae: a multi-omics review perspective

S Ali, M Alam, GM Hasan… - Briefings in functional …, 2022 - academic.oup.com
The multidrug resistance developed in many organisms due to the prolonged use of
antibiotics has been an increasing global health crisis. Klebsiella pneumoniae is a causal …

Targeting the Sugary Armor of Klebsiella Species

LPP Patro, T Rathinavelan - Frontiers in cellular and infection …, 2019 - frontiersin.org
The emergence of multidrug-resistant strains of Gram-negative Klebsiella species is an
urgent global threat. The World Health Organization has listed Klebsiella pneumoniae as …

Insights into computational drug repurposing for neurodegenerative disease

MD Paranjpe, A Taubes, M Sirota - Trends in pharmacological sciences, 2019 - cell.com
Computational drug repurposing has the ability to remarkably reduce drug development
time and cost in an era where these factors are prohibitively high. Several examples of …

Omics of antimicrobials and antimicrobial resistance

VM Chernov, OA Chernova… - Expert opinion on …, 2019 - Taylor & Francis
Introduction: The development of new antimicrobials has become an urgent priority because
of a global challenge emerging from the rise of antimicrobial resistant pathogens. Areas …

Identification of potential flavonoid compounds as antibacterial therapeutics against Klebsiella pneumoniae infection using structure-based virtual screening and …

J Dey, SR Mahapatra, TK Raj, N Misra, M Suar - Molecular Diversity, 2023 - Springer
Klebsiella pneumoniae, which is among the top three pathogens on WHO's priority list, is
one of the gram-negative bacteria that doctors and researchers around the world have …

Omics for bioprospecting and drug discovery from bacteria and microalgae

R Maghembe, D Damian, A Makaranga, SS Nyandoro… - Antibiotics, 2020 - mdpi.com
“Omics” represent a combinatorial approach to high-throughput analysis of biological
entities for various purposes. It broadly encompasses genomics, transcriptomics …