Modified vaccinia virus Ankara: history, value in basic research, and current perspectives for vaccine development
A Volz, G Sutter - Advances in virus research, 2017 - Elsevier
Abstract Safety tested Modified Vaccinia virus Ankara (MVA) is licensed as third-generation
vaccine against smallpox and serves as a potent vector system for development of new …
vaccine against smallpox and serves as a potent vector system for development of new …
CRISPR-Cas9 for cancer therapy: Opportunities and challenges
Cancer is a genetic disease stemming from cumulative genetic/epigenetic aberrations.
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas9-mediated …
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas9-mediated …
DNA-free genome editing: past, present and future
J Metje-Sprink, J Menz, D Modrzejewski… - Frontiers in Plant …, 2019 - frontiersin.org
Genome Editing using engineered endonuclease (GEEN) systems rapidly took over the field
of plant science and plant breeding. So far, Genome Editing techniques have been applied …
of plant science and plant breeding. So far, Genome Editing techniques have been applied …
[HTML][HTML] CRISPR/Cas9-derived mutations both inhibit HIV-1 replication and accelerate viral escape
Z Wang, Q Pan, P Gendron, W Zhu, F Guo, S Cen… - Cell reports, 2016 - cell.com
Cas9 cleaves specific DNA sequences with the assistance of a programmable single guide
RNA (sgRNA). Repairing this broken DNA by the cell's error-prone non-homologous end …
RNA (sgRNA). Repairing this broken DNA by the cell's error-prone non-homologous end …
A CRISPR toolbox to study virus–host interactions
Viruses depend on their hosts to complete their replication cycles; they exploit cellular
receptors for entry and hijack cellular functions to replicate their genome, assemble progeny …
receptors for entry and hijack cellular functions to replicate their genome, assemble progeny …
CRISPR/Cas: from tumor gene editing to T cell-based immunotherapy of cancer
The clustered regularly interspaced short palindromic repeats system has demonstrated
considerable advantages over other nuclease-based genome editing tools due to its high …
considerable advantages over other nuclease-based genome editing tools due to its high …
Efficient inhibition of African swine fever virus replication by CRISPR/Cas9 targeting of the viral p30 gene (CP204L)
A Hübner, B Petersen, GM Keil, H Niemann… - Scientific reports, 2018 - nature.com
African swine fever is a devastating viral disease of domestic and wild pigs against which no
vaccine or therapy is available. Therefore, we applied the CRISPR (clustered regularly …
vaccine or therapy is available. Therefore, we applied the CRISPR (clustered regularly …
CRISPR-Cas9 therapeutics in cancer: promising strategies and present challenges
L Yi, J Li - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2016 - Elsevier
Cancer is characterized by multiple genetic and epigenetic alterations that drive malignant
cell proliferation and confer chemoresistance. The ability to correct or ablate such mutations …
cell proliferation and confer chemoresistance. The ability to correct or ablate such mutations …
CRISPR-Cas9, a tool to efficiently increase the development of recombinant African swine fever viruses
African swine fever virus (ASFV) causes a highly contagious disease called African swine
fever. This disease is often lethal for domestic pigs, causing extensive losses for the swine …
fever. This disease is often lethal for domestic pigs, causing extensive losses for the swine …
[HTML][HTML] A simple and rapid approach to develop recombinant avian herpesvirus vectored vaccines using CRISPR/Cas9 system
Herpesvirus of turkeys (HVT) has been successfully used as live vaccine against Marek's
disease (MD) worldwide for more than 40 years either alone or in combination with other …
disease (MD) worldwide for more than 40 years either alone or in combination with other …