There is increasing evidence regarding the prevalence of genetic cardiomyopathies, for
which arrhythmias may be the first presentation. Ventricular and atrial arrhythmias …

Voltage-gated proton channels (HV) are unique, in part because the ion they conduct is
unique. HV channels are perfectly selective for protons and have a very small unitary …

The gene SCN5A encodes the main cardiac sodium channel Na V 1.5. This channel
predominates the cardiac sodium current, I Na, which underlies the fast upstroke of the …

The SCN5A gene encodes the alpha subunit of the main cardiac sodium channel Nav1. 5.
This channel predominates inward sodium current (INa) and plays a critical role in …

Over the last two decades, an increasing number of SCN5A mutations have been described
in patients with long QT syndrome type 3 (LQT3), Brugada syndrome,(progressive) …

Influx of sodium ions through voltage-gated sodium channels in cardiomyocytes is essential
for proper electrical conduction within the heart. Both acquired conditions associated with …

Background: The hypothesis of the Dilated Cardiomyopathy Precision Medicine Study is that
most dilated cardiomyopathy has a genetic basis. The study returns results to probands and …

The cardiac sodium channel NaV1. 5, encoded by the SCN5A gene, is responsible for the
fast upstroke of the action potential. Mutations in SCN5A may cause sodium channel …

The SCN5A gene encodes the alpha-subunit of the Na v 1.5 ion channel protein, which is
responsible for the sodium inward current (I Na). Since 1995 several hundred mutations in …

Mutations of the voltage-gated sodium channel SCN8A have been identified in
approximately 1% of nearly 1,500 children with early-infantile epileptic encephalopathies …