Heterocyclic N-oxides-an emerging class of therapeutic agents
AM Mfuh, OV Larionov - Current medicinal chemistry, 2015 - ingentaconnect.com
Heterocyclic N-oxides have emerged as potent compounds with anticancer, antibacterial,
antihypertensive, antiparasitic, anti-HIV, anti-inflammatory, herbicidal, neuroprotective, and …
antihypertensive, antiparasitic, anti-HIV, anti-inflammatory, herbicidal, neuroprotective, and …
[HTML][HTML] Molecular mechanisms underlying airway smooth muscle contraction and proliferation: implications for asthma
G Pelaia, T Renda, L Gallelli, A Vatrella, MT Busceti… - Respiratory …, 2008 - Elsevier
Airway smooth muscle (ASM) plays a key role in bronchomotor tone, as well as in structural
remodeling of the bronchial wall. Therefore, ASM contraction and proliferation significantly …
remodeling of the bronchial wall. Therefore, ASM contraction and proliferation significantly …
Tissue regeneration and in loco administration of platelet derivatives: clinical outcome, heterogeneous products, and heterogeneity of the effector mechanisms
P Borzini, L Mazzucco - Transfusion, 2005 - Wiley Online Library
BACKGROUND: In loco administration of platelet (PLT) derivatives is a relatively new
auxiliary treatment for tissue regeneration to be hastened. Enthusiastic reports are faced by …
auxiliary treatment for tissue regeneration to be hastened. Enthusiastic reports are faced by …
FGF2, an immunomodulatory factor in asthma and chronic obstructive pulmonary disease (COPD)
Y Tan, Y Qiao, Z Chen, J Liu, Y Guo, T Tran… - Frontiers in cell and …, 2020 - frontiersin.org
The fibroblast growth factor 2 (FGF2) is a potent mitogenic factor belonging to the FGF
family. It plays a role in airway remodeling associated with chronic inflammatory airway …
family. It plays a role in airway remodeling associated with chronic inflammatory airway …
Vascular smooth muscle cells for use in vascular tissue engineering obtained by endothelial-to-mesenchymal transdifferentiation (EnMT) on collagen matrices
G Krenning, JRAJ Moonen, MJA van Luyn… - Biomaterials, 2008 - Elsevier
The discovery of the endothelial progenitor cell (EPC) has led to an intensive research effort
into progenitor cell-based tissue engineering of (small-diameter) blood vessels. Herein, EPC …
into progenitor cell-based tissue engineering of (small-diameter) blood vessels. Herein, EPC …
Cigarette smoke and lipopolysaccharide induce a proliferative airway smooth muscle phenotype
Background A major feature of chronic obstructive pulmonary disease (COPD) is airway
remodelling, which includes an increased airway smooth muscle (ASM) mass. The …
remodelling, which includes an increased airway smooth muscle (ASM) mass. The …
Cellular microenvironment stiffness regulates eicosanoid production and signaling pathways
Pathological changes in the biomechanical environment are implicated in the progression of
idiopathic pulmonary fibrosis (IPF). Stiffened matrix augments fibroblast proliferation and …
idiopathic pulmonary fibrosis (IPF). Stiffened matrix augments fibroblast proliferation and …
Airway epithelium stimulates smooth muscle proliferation
Communication between the airway epithelium and stroma is evident during
embryogenesis, and both epithelial shedding and increased smooth muscle proliferation are …
embryogenesis, and both epithelial shedding and increased smooth muscle proliferation are …
Fibroblast growth factor 2 and transforming growth factor β1 synergism in human bronchial smooth muscle cell proliferation
Y Bossé, C Thompson, J Stankova… - American journal of …, 2006 - atsjournals.org
Bronchial smooth muscle cell (BSMC) hyperplasia is a typical feature of airway remodeling
and contributes to airway obstruction and hyperresponsiveness in asthma. Fibroblast growth …
and contributes to airway obstruction and hyperresponsiveness in asthma. Fibroblast growth …
Crosstalk between signaling pathways involved in the regulation of airway smooth muscle cell hyperplasia
Increased ASM mass, primarily due to ASM hyperplasia, has been recognized as a hallmark
of airway remodeling in asthma. Increased ASM mass is the major contributor to the airway …
of airway remodeling in asthma. Increased ASM mass is the major contributor to the airway …