Heritable variation in gene expression is common within and between species. This
variation arises from mutations that alter the form or function of molecular gene regulatory …

Heritable variation in gene expression forms a crucial bridge between genomic variation
and the biology of many traits. However, most expression quantitative trait loci (eQTLs) …

Highlights•Cis-and trans-acting mutations contribute differently to gene expression
evolution.•Cis-regulatory variants often have larger effects and alter expression of fewer …

Variation in gene expression arises from cis-and trans-regulatory mutations, which
contribute differentially to expression divergence. We compare the impacts on gene …

Gene expression noise is an evolvable property of biological systems that describes
differences in expression among genetically identical cells in the same environment. Prior …

The effects of cell-to-cell variation (noise) in gene expression have proven difficult to quantify
because of the mechanistic coupling of noise to mean expression. To independently …

DNA variants that alter gene expression contribute to variation in many phenotypic traits. In
particular, trans-acting variants, which are often located on different chromosomes from the …

The early development of aneuploidy from an accidental chromosome missegregation
shows contrasting effects. On the one hand, it is associated with significant cellular stress …

Genetic networks are surprisingly robust to perturbations caused by new mutations. This
robustness is conferred in part by compensation for loss of a gene's activity by genes with …

Background In synthetic biology, the strength of promoter elements is the basis for precise
regulation of target gene transcription levels, which in turn increases the yield of the target …