Papillomavirus immune evasion strategies target the infected cell and the local immune system

C Zhou, ZK Tuong, IH Frazer - Frontiers in oncology, 2019 - frontiersin.org
Persistent infection with human papillomavirus (HPV) initiates~ 5% of all human cancers,
and particularly cervical and oropharyngeal cancers. HPV vaccines prevent HPV infection …

The immune microenvironment in human papilloma virus-induced cervical lesions—Evidence for estrogen as an immunomodulator

J Rs - Frontiers in Cellular and Infection Microbiology, 2021 - frontiersin.org
Globally, human papilloma virus (HPV) infection is a common sexually transmitted disease.
However, most of the HPV infections eventually resolve aided by the body's efficient cell …

Current therapeutic vaccination and immunotherapy strategies for HPV-related diseases

JG Skeate, AW Woodham, MH Einstein… - Human vaccines & …, 2016 - Taylor & Francis
Carcinomas of the anogenital tract, in particular cervical cancer, remains one of the most
common cancers in women, and represent the most frequent gynecological malignancies …

CXCL14 suppresses human papillomavirus-associated head and neck cancer through antigen-specific CD8+ T-cell responses by upregulating MHC-I expression

JA Westrich, DW Vermeer, A Silva, S Bonney… - Oncogene, 2019 - nature.com
Evasion of the host immune responses is critical for both persistent human papillomavirus
(HPV) infection and associated cancer progression. We have previously shown that …

Immunotherapeutic approaches for the treatment of HPV-associated (pre-) cancer of the cervix, vulva and penis

TS Rafael, J Rotman, OR Brouwer… - Journal of Clinical …, 2022 - mdpi.com
Human papillomavirus (HPV) infection drives tumorigenesis in almost all cervical cancers
and a fraction of vulvar and penile cancers. Due to increasing incidence and low vaccination …

[HTML][HTML] Poly (I: C) treatment prevents skin tumor formation in the preclinical HPV8 transgenic mouse model

M Hufbauer, S Rattay, C Hagen, A Quaas… - Journal of Investigative …, 2023 - Elsevier
Actinic keratoses and cutaneous squamous cell carcinomas are associated with infections
with human papillomavirus of genus beta (betaHPV) in immunosuppressed patients. To …

The interaction between human papillomaviruses and the stromal microenvironment

B Woodby, M Scott, J Bodily - … in molecular biology and translational science, 2016 - Elsevier
Human papillomaviruses (HPVs) are small, double-stranded DNA viruses that replicate in
stratified squamous epithelia and cause a variety of malignancies. Current efforts in HPV …

Langerhans cells from women with cervical precancerous lesions become functionally responsive against human papillomavirus after activation with stabilized Poly-I …

DM Da Silva, AW Woodham, JG Skeate, LK Rijkee… - Clinical …, 2015 - Elsevier
Human papillomavirus (HPV)-mediated suppression of Langerhans cell (LC) function can
lead to persistent infection and development of cervical intraepithelial neoplasia (CIN) …

[HTML][HTML] Intratumoural immunotherapy: activation of nucleic acid sensing pattern recognition receptors

S Agrawal, ER Kandimalla - Immuno-Oncology Technology, 2019 - Elsevier
Recently, it has become clear that the tumour microenvironment (TME) is important in cancer
immunotherapy. While immune checkpoint inhibitors are effective for some patients, the …

A model of impaired Langerhans cell maturation associated with HPV induced epithelial hyperplasia

ZK Tuong, SW Lukowski, QH Nguyen, J Chandra… - Iscience, 2021 - cell.com
Langerhans cells (LC) are skin-resident antigen-presenting cells that regulate immune
responses to epithelial microorganisms. Human papillomavirus (HPV) infection can promote …