Snake venoms have components with diverse biological actions that are extensively studied
to identify elements that may be useful in biomedical sciences. In the field of autoimmunity …

1 We have characterized the constrictor endothelin receptors present in human isolated
blood vessels using ETA and ETB selective agonists and antagonists. 2 Monophasic dose …

It is known that binding sites with endothelinA (ET) A and ETB receptor characteristics
coexist in human heart but little is known about the receptors that mediate cardiostimulant …

Endothelin (ET) peptides perform several physiological, vascular, and nonvascular functions
and are widely distributed in a number of tissues. They are altered in several disease …

Background Endothelin-1 (ET-1) is a potent vasoconstrictor produced from the precursor big
ET-1 in endothelial cells. The coronary effects of these peptides in humans in vivo are …

1 We have characterized the human smooth muscle endothelin converting enzyme (ECE)
present in the media of the endothelium‐denuded human umbilical vein preparation. 2 …

The ability of the putative chymase product of big endothelin‐1 (big ET‐1), ET‐1 (1–31), to
constrict isolated endothelium‐denuded preparations of human coronary and internal …

Abstract Endothelin A (ET A) and ET B receptors located on vascular smooth-muscle cells
mediate potent vasoconstriction in animal and human blood vessels. Although vascular …

Endothelin receptors (ETA and ETB) mediate responses to ET-1. ETB receptor function
seems to differ between a similarly sized arterial and venous pair, the rat vena cava (RVC) …

Our aim was to determine whether the expression of endothelin-converting enzyme in
human tissues would correlate with the distribution of its substrate, big endothelin-1, and its …