Nanofluidic structures have over the last two decades emerged as a powerful platform for
detailed analysis of DNA on the kilobase pair length scale. When DNA is confined to a …

In recent years, applications and experimental studies of DNA in nanochannels have
stimulated the investigation of the polymer physics of DNA in confinement. Recent advances …

DNA confined to nanofluidic channels with a cross-section from tens to hundreds of nm wide
and hundreds of microns long stretches in an equilibrium process free of flow or end …

Studies of circular DNA confined to nanofluidic channels are relevant both from a
fundamental polymer-physics perspective and due to the importance of circular DNA …

DNA double strand breaks (DSBs) can be detrimental to the cell and need to be efficiently
repaired. A first step in DSB repair is to bring the free ends in close proximity to enable …

Semiflexible polymers are ubiquitous in biological systems, eg, as building blocks of the
cytoskeleton, and they also play an important role in various materials due to their ability to …

DNA–protein interactions are at the core of the cellular machinery and single molecule
methods have revolutionized the possibilities to study, and our understanding of these …

Biosensing plays a vital role in healthcare monitoring, disease detection, and treatment
planning. In recent years, nanofluidic technology has been increasingly explored to be …

Nanochannels provide a means for detailed experiments on the effect of confinement on
biomacromolecules, such as DNA. Here we introduce a model for the complete unfolding of …

We present a nanofluidic device for targeted manipulations in the quarternary structure of
single DNA molecules. We demonstrate the folding and unfolding of hairpin-shaped regions …