Thyroid iodide uptake is basic to the clinical applications of radioiodine. Iodide uptake
occurs across the membrane of the thyroid follicular cells through an active transporter …

The sodium/iodide symporter (NIS) mediates iodide uptake in the thyroid gland and lactating
breast. NIS mRNA and protein expression are detected in most thyroid cancer specimens …

BACKGROUND To investigate the role of primary hypothyroidism (HYPT) on breast
carcinogenesis, the authors evaluated 1) the association between HYPT and a diagnosis of …

The sodium iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates
the active transport of iodide in the thyroid gland and a number of extrathyroidal tissues, in …

An association between breast cancer and thyroid (autoimmune) diseases or the presence
of thyroid peroxidase antibodies (TPOAb; a marker of thyroid autoimmune disease) has …

The role played in thyroid hormonogenesis by iodide oxidation to iodine (organification) is
well established. Iodine deficiency may produce conditions of oxidative stress with high TSH …

Active transport of iodide into the thyroid gland is a crucial and rate-limiting step in the
biosynthesis of thyroid hormones that play an important role in the metabolism, growth, and …

Pertechnetate (as 99mTcO4−), 123I−, and 131I− have a long and successful history of use in
the diagnosis and therapy of thyroid cancer, with uptake into thyroid tissue mediated by the …

The sodium/iodide symporter (NIS) stimulates iodide uptake in normal lactating breast, but is
not known to be active in nonlactating breast or breast cancer. We studied NIS gene …

It is hypothesized that dietary iodine deficiency is associated with the development of
mammary pathology and cancer. A review of the literature on this correlation and of the …