Amyloid formation typically follows a time course in which there is a long lag period followed
by a rapid formation of fibrils. In this review, I show that the standard mechanisms of …

Membrane encapsulation is frequently used by the cell to sequester biomolecules and
compartmentalize their function. Cells also concentrate molecules into phase-separated …

Thanks to recent improvements in NMR instrumentation, pulse sequence design, and
sample preparation, a panoply of new NMR tools has become available for atomic …

Disordered proteins play an essential role in a wide variety of biological processes, and are
often posttranslationally modified. One such protein is histone H1; its highly disordered C …

Alzheimer disease is characterized by abnormal protein deposits in the brain, such as
extracellular amyloid plaques and intracellular neurofibrillary tangles. The tangles are made …

The aggregation of the microtubule-associated tau protein and formation of" neurofibrillary
tangles" is one of the hallmarks of Alzheimer disease. The mechanisms underlying the …

The characterization of the conformational properties of intrinsically disordered proteins
(IDPs), and their interaction modes with physiological partners has recently become a major …

The ϕ, ψ backbone angle distribution of small homopolymeric model peptides is
investigated by a joint molecular dynamics (MD) simulation and heteronuclear NMR study …

Adhesive interactions involving CD44, the cell surface receptor for hyaluronan, underlie
fundamental processes such as inflammatory leukocyte homing and tumor metastasis …

α-Synuclein is an intrinsically disordered protein that appears in aggregated forms in the
brains of patients with Parkinson's disease. The conversion from monomer to aggregate is …