Communication between the immune and the nervous system is essential for human brain
development and homeostasis. Disruption of this intricately regulated crosstalk can lead to …

Anti-glial fibrillary acidic protein (GFAP) meningoencephalomyelitis (autoimmune GFAP
astrocytopathy) is a new autoimmune central nervous system (CNS) disease diagnosable by …

Highlights•Embryonic stem cell-derived glia cell types.•Protocols to generate glia in
vitro.•Glial-derived cues playing roles in CNS disease progression.•Glial-derived CNS …

Emerging evidence of species divergent features of astrocytes coupled with the relative
inaccessibility of human brain tissue underscore the utility of human pluripotent stem cell …

Astrocytes, the predominant glial cells in the central nervous system, play essential roles in
maintaining brain function. Reprogramming induced pluripotent stem cells (iPSCs) to …

Astrocytes, the most abundant glial cell type in the brain, play crucial roles in maintaining
homeostasis within the central nervous system (CNS). Impairment or abnormalities of typical …

Current diagnostic methods for prion diseases only work in late stages of the disease when
neurodegeneration is irreversible. Therefore, biomarkers that can detect the disease before …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by a
progressive loss of motor function linked to degenerating extratelencephalic neurons/Betz …

There exist over 600 neurological conditions, each characterized by unique pathologies
tailored to individual patients. Over the past two decades, advances in biotechnology have …

Down syndrome (DS), or trisomy 21 (T21), resulting from an extra copy of chromosome 21,
occurs in 1 in 700–1,000 live births. Neuroinflammation is increasingly recognized as a …