In light of the Covid-19 outbreak, this review brings together historical and current literature
efforts towards the development of antiviral metallodrugs. Classical compounds such as …

Integration of a desossiribonucleic acid (DNA) copy of the viral ribonucleic acid (RNA) into
host genomes is a fundamental step in the replication cycle of all retroviruses. The highly …

HIV-1 integrase (IN) is a validated therapeutic target for antiviral drug design. However, the
emergence of viral strains resistant to clinically studied IN inhibitors demands the discovery …

2-Hydroxyisoquinoline-1, 3 (2 H, 4 H)-dione was recently discovered as a scaffold for the
inhibition of HIV-1 integrase and the ribonuclease H function of HIV-1 reverse transcriptase …

Bictegravir and dolutegravir are two recently approved integrase inhibitors for the treatment
of HIV. A third inhibitor, cabotegravir, is in Phase 3 development. As a continuation of a …

New drugs introduced to the market every year represent privileged structures for particular
biological targets. These new chemical entities (NCEs) provide insight into molecular …

Acquired immune deficiency syndrome (AIDS)/human immunodeficiency virus (HIV) is one
of the largest and most devastating public health pandemics throughout the world. The …

1, 2-bis-(2-pyren-1-ylmethylamino-ethoxy) ethane (NPEY) was synthesized and brought to
the surface of graphene nanosheets (GNs) via π–π stacking, which provided a simple and …

Metal-activated enzymes are important targets in drug discovery in general and for antivirals
in particular. Such proteins contain one or more metal ion cofactors, prevalently located in …

HIV infection is a major challenge to mankind and a definitive cure or a viable vaccine for
HIV is still elusive. HIV-1 is constantly evolving and developing resistant against clinically …