Chagas disease is a neglected tropical disease caused by the flagellated protozoa
Trypanosoma cruzi that affects several million people mainly in Latin American countries …

Introduction Benznidazole, the drug of choice for treating Chagas Disease (CD), has
significant limitations, such as poor cure efficacy, mainly in the chronic phase of CD …

Introduction Trypanosoma cruzi, the causative agent of Chagas disease, can infect almost
any nucleated cell in the mammalian host. Although previous studies have described the …

Cruzain, the main cysteine protease of Trypanosoma cruzi, plays key roles in all stages of
the parasite's life cycle, including nutrition acquisition, differentiation, evasion of the host …

Background Chagas disease can lead to life-threatening cardiac manifestations. Regional
factors, including genetic characteristics of circulating Trypanosoma cruzi (T. cruzi), have …

Proximity labelling is a powerful and rapidly developing technology for exploring the
interaction space and molecular environment of a protein of interest at the nanometre scale …

Trypanosoma cruzi is a flagellated protozoan parasite which causes Chagas disease or
American trypanosomiasis. In its life cycle it has haematophagous triatomine insects and …

A doença de Chagas é uma antropozoonose tropical causada pela infecção do parasita
Trypanosoma cruzi (T. cruzi) em humanos. A doença se inicia na fase aguda, por vezes …

Der Lebenszyklus der Parasiten ist komplex und umfasst verschiedene morphologische und
biochemische Anpassungen, die sich in pleomorphen Lebensformen in Vektor und Wirt …