Despite advancements in standardizing the criteria for acute kidney injury (AKI), its definition
remains based on changes in serum creatinine and urinary output that do not specifically …

Autosomal dominant tubulointerstitial kidney disease (ADTKD) is a recently defined entity
that includes rare kidney diseases characterized by tubular damage and interstitial fibrosis …

Uromodulin, a protein exclusively produced by the kidney, is the most abundant urinary
protein in physiological conditions. Already described several decades ago, uromodulin has …

Kidney lifespan is a patient-oriented outcome that provides much needed context for
understanding chronic kidney disease (CKD). Nephron endowment, age-associated decline …

Urinary extracellular vesicles (uEVs) are emerging as non‐invasive biomarkers for various
kidney diseases, but it is unknown how differences in nephron mass impact uEV excretion …

Biology has taught us that a protein as abundantly made and conserved among species as
Tamm–Horsfall protein (THP or uromodulin) cannot just be a waste product serving no …

The identification of genetic factors associated with the risk, onset, and progression of kidney
disease has the potential to provide mechanistic insights and therapeutic perspectives. In …

Identifying new AKI biomarkers is a priority in pediatric nephrology research because of the
morbidity associated with AKI, as well as the lack of therapies for AKI. Recent research …

The human Sec61 complex is a widely distributed and abundant molecular machine. It
resides in the membrane of the endoplasmic reticulum to channel two types of cargo: protein …

Results The mean age of participants was 60±12 years, 60% were male. Mean serum
uromodulin concentration was 98±60 ng/ml, eGFR was 49±18 ml/min per 1.73 m 2, and …