Small vessel disease is a disorder of cerebral microvessels that causes white matter
hyperintensities and several other common abnormalities (eg, recent small subcortical …

Hypertension has emerged as a leading cause of age-related cognitive impairment. Long
known to be associated with dementia caused by vascular factors, hypertension has more …

Hypertension affects a significant proportion of the adult and aging population and
represents an important risk factor for vascular cognitive impairment and late-life dementia …

Increasing evidence suggests that vascular risk factors contribute to neurodegeneration,
cognitive impairment and dementia. While there is considerable overlap between features of …

Objective Because the role of white matter (WM) degenerating microglia (DM) in
remyelination failure is unclear, we sought to define the core features of this novel …

Ischemic stroke lesion and white matter hyperintensity (WMH) lesion appear as regions of
abnormally signal intensity on magnetic resonance image (MRI) sequences. Ischemic stroke …

Vascular cognitive impairment and dementia (VCID) include a wide spectrum of chronic
manifestations of vascular disease related to large vessel strokes and small vessel disease …

Cerebral small vessel disease (cSVD) refers to the age-dependent pathological processes
involving the brain small vessels and leading to vascular cognitive impairment, intracerebral …

Objective To investigate cerebrovascular reactivity (CVR), blood flow, vascular and CSF
pulsatility, and their independent relationship with cerebral small vessel disease (SVD) …

Cerebral small vessel disease (CSVD) has emerged as a common factor driving age-
dependent diseases, including stroke and dementia. CSVD-related dementia will affect a …