Osthole: An overview of its sources, biological activities, and modification development

M Sun, M Sun, J Zhang - Medicinal Chemistry Research, 2021 - Springer
Osthole, also known as osthol, is a coumarin derivative found in several medicinal plants
such as Cnidium monnieri and Angelica pubescens. It can be obtained via extraction and …

Bridging the gap between physical health and autism spectrum disorder

R Sala, L Amet, N Blagojevic-Stokic… - Neuropsychiatric …, 2020 - Taylor & Francis
Autism spectrum disorder (ASD) is a highly complex and heterogeneous developmental
disorder that affects how individuals communicate with other people and relate to the world …

Prangos ferulacea (L.) ameliorates behavioral alterations, hippocampal oxidative stress markers, and apoptotic deficits in a rat model of autism induced by valproic …

M Saadat, AA Taherian, MR Aldaghi… - Brain and …, 2023 - Wiley Online Library
Background Prenatal exposure to valproic acid (VPA) may enhance the risk of autism
spectrum disorder (ASD) in children. This study investigated the effect of Prangos ferulacea …

Serum cytokine levels in children with spectrum autism disorder: Differences in pro-and anti-inflammatory balance

NK Kordulewska, E Kostyra, K Piskorz-Ogórek… - Journal of …, 2019 - Elsevier
Abstract Background Autism Spectrum Disorders (ASDs) is a developmental and
neurological disorder that affects all aspects of social communication, with limited and …

Paediatric asthma and non‐allergic comorbidities: A review of current risk and proposed mechanisms

BK Brew, EC Osvald, T Gong… - Clinical & …, 2022 - Wiley Online Library
It is increasingly recognized that children with asthma are at a higher risk of other non‐
allergic concurrent diseases than the non‐asthma population. A plethora of recent research …

Neuronal cell adhesion molecules may mediate neuroinflammation in autism spectrum disorder

M Eve, J Gandawijaya, L Yang… - Frontiers in Psychiatry, 2022 - frontiersin.org
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized
by restrictive and repetitive behaviors, alongside deficits in social interaction and …

Modulatory effects of osthole on lipopolysaccharides-induced inflammation in Caco-2 cell monolayer and co-cultures with THP-1 and THP-1-derived macrophages

NK Kordulewska, J Topa, M Tańska, A Cieślińska… - Nutrients, 2020 - mdpi.com
Lipopolysaccharydes (LPS) are responsible for the intestinal inflammatory reaction, as they
may disrupt tight junctions and induce cytokines (CKs) secretion. Osthole has a wide …

The immune system and autism spectrum disorder: association and therapeutic challenges

A Heidari, Y Rostam-Abadi, N Rezaei - Acta neurobiologiae experimentalis, 2021 - ane.pl
Autism spectrum disorder (ASD) is a neurodevelopmental disorder, affecting communication
and behavior. Historically, ASD had been described as a purely psychiatric disorder with …

The Role of Osthole on TGF‐β‐Induced Lung Epithelium Apoptosis Injury and Epithelial‐Mesenchymal Transition‐Mediated Airway Remodeling in Pediatric Asthma

J Tang, J Liu, X Zhang - Journal of Healthcare Engineering, 2022 - Wiley Online Library
Osthole, a coumarin compound derived from Fructus Cnidii, exerts anti‐inflammatory effects
in an asthma model. But the effect of osthole on epithelial injury and epithelial …

Osthole: synthesis, structural modifications, and biological properties

Z Ren, M Lv, H Xu - Mini Reviews in Medicinal Chemistry, 2022 - ingentaconnect.com
Osthole, a naturally occurring coumarin-type compound, is isolated from the Chinese herbal
medicine Cnidium monnieri (L.) and exhibits a broad range of biological properties. In this …