Ubiquitination plays a pivotal role in several cellular processes and is critical for protein
degradation and signaling. E3 ubiquitin ligases are the matchmakers in the ubiquitination …

Despite all the other cells that have the potential to prevent cancer development and
metastasis through tumour suppressor proteins, cancer cells can upregulate the ubiquitin …

Background: Tumor models are critical for our understanding of cancer and the development
of cancer therapeutics. The 4T1 murine mammary cancer cell line is one of the most widely …

The transition from mitosis to interphase, referred to as mitotic exit, is a critical mitotic
process which involves activation and inactivation of multiple mitotic kinases and …

We intended to evaluate miR‐490‐5p expression in hepatocellular carcinoma (HCC) tissues
and detect the potential targets of miR‐490‐5p. In vitro experiments were conducted to …

Background OTUB1 (ovarian tumor domain protease domain-containing ubiquitin aldehyde-
binding proteins)-mediated deubiquitination of FOXM1 (Forkhead box M1) participates in …

Purpose This research was to investigate the role of miR-223-3p targeting epithelial cell
transforming sequence 2 oncogene (ECT2) in activity, apoptosis, invasion and migration of …

Ubiquitin modification plays significant roles in protein fate determination, signaling
transduction, and cellular processes. Over the past 2 decades, the number of studies on …

Prostate cancer (PC) is the most common cancer in men. Elevated levels of E3 ligase, E6-
Associated Protein (E6AP) were previously linked to PC, consistent with increased protein …

Rationale: A number of guanine nucleotide exchange factors (GEFs) including epithelial cell
transforming factor ECT2 are believed to drive carcinogenesis through activating distinct …