Hyaluronic acid: A key ingredient in the therapy of inflammation
A Marinho, C Nunes, S Reis - Biomolecules, 2021 - mdpi.com
Hyaluronic acid (HA) is a natural polymer, produced endogenously by the human body,
which has unique physicochemical and biological properties, exhibiting desirable …
which has unique physicochemical and biological properties, exhibiting desirable …
May the force be with you (or not): The immune system under microgravity
All terrestrial organisms have evolved and adapted to thrive under Earth's gravitational force.
Due to the increase of crewed space flights in recent years, it is vital to understand how the …
Due to the increase of crewed space flights in recent years, it is vital to understand how the …
3D in vitro M2 macrophage model to mimic modulation of tissue repair
Distinct anti-inflammatory macrophage (M2) subtypes, namely M2a and M2c, are reported to
modulate the tissue repair process tightly and chronologically by modulating fibroblast …
modulate the tissue repair process tightly and chronologically by modulating fibroblast …
Collagen fibril orientation instructs fibroblast differentiation via cell contractility
Collagen alignment is one of the key microarchitectural signatures of many pathological
conditions, including scarring and fibrosis. Investigating how collagen alignment modulates …
conditions, including scarring and fibrosis. Investigating how collagen alignment modulates …
Collagen fibril density modulates macrophage activation and cellular functions during tissue repair
J Sapudom, WKE Mohamed, A Garcia-Sabaté… - Bioengineering, 2020 - mdpi.com
Monocytes circulate in the bloodstream, extravasate into the tissue and differentiate into
specific macrophage phenotypes to fulfill the immunological needs of tissues. During the …
specific macrophage phenotypes to fulfill the immunological needs of tissues. During the …
Matrix remodeling and hyaluronan production by myofibroblasts and cancer-associated fibroblasts in 3D collagen matrices
The tumor microenvironment is a key modulator in cancer progression and has become a
novel target in cancer therapy. An increase in hyaluronan (HA) accumulation and …
novel target in cancer therapy. An increase in hyaluronan (HA) accumulation and …
Dendritic cell immune potency on 2D and in 3D collagen matrices
Dendritic cells (DCs) are antigen-presenting cells capable of either activating the immune
response or inducing and maintaining immune tolerance. Understanding how biophysical …
response or inducing and maintaining immune tolerance. Understanding how biophysical …
Fibroblast differentiation and matrix remodeling impaired under simulated microgravity in 3D cell culture model
Exposure to microgravity affects astronauts' health in adverse ways. However, less is known
about the extent to which fibroblast differentiation during the wound healing process is …
about the extent to which fibroblast differentiation during the wound healing process is …
[HTML][HTML] M1 macrophages induce protumor inflammation in melanoma cells through TNFR–NF-κB signaling
K Kainulainen, P Takabe, S Heikkinen… - Journal of Investigative …, 2022 - Elsevier
The tumor microenvironment, with distinctive cell types and a complex extracellular matrix
has a tremendous impact on cancer progression. In this study, we investigated the effects of …
has a tremendous impact on cancer progression. In this study, we investigated the effects of …
Cancer cell migration in collagen-hyaluronan composite extracellular matrices
Hyaluronan (HA) is a key component in the tumor microenvironment (TME) that participates
in cancer growth and invasiveness. While the molecular weight (MW) dependent properties …
in cancer growth and invasiveness. While the molecular weight (MW) dependent properties …