DNA methylation in lung cancer: mechanisms and associations with histological subtypes, molecular alterations, and major epidemiological factors

PH Hoang, MT Landi - Cancers, 2022 - mdpi.com
Simple Summary Aberrant DNA methylation is associated with multiple malignancies,
including lung cancer. Differences in methylation patterns have been observed across lung …

Vaping, environmental toxicants exposure, and lung cancer risk

SA Shehata, EA Toraih, EA Ismail, AM Hagras… - Cancers, 2023 - mdpi.com
Simple Summary Lung cancer (LC) is considered one of the most common cancers globally.
Numerous studies have determined the relations between E-cigarette, or vaping, products …

Genomic and evolutionary classification of lung cancer in never smokers

T Zhang, P Joubert, N Ansari-Pour, W Zhao… - Nature …, 2021 - nature.com
Lung cancer in never smokers (LCINS) is a common cause of cancer mortality but its
genomic landscape is poorly characterized. Here high-coverage whole-genome sequencing …

[HTML][HTML] Lung cancer risk in never-smokers: An overview of environmental and genetic factors

ES Cheng, M Weber, J Steinberg… - Chinese Journal of …, 2021 - ncbi.nlm.nih.gov
Lung cancer is the leading cause of cancer-related mortality globally, accounting for 1.8
million deaths in 2020. While the vast majority are caused by tobacco smoking, 15%− 25 …

Mutational Signatures in Gastric Cancer and Their Clinical Implications

P Pužar Dominkuš, P Hudler - Cancers, 2023 - mdpi.com
Simple Summary There is a lack of molecular biomarkers that would allow better
characterisation and categorisation of gastric tumours. Distinct mutational patterns have …

[HTML][HTML] Secondary prevention and treatment innovation of early stage non-small cell lung cancer: Impact on diagnostic-therapeutic pathway from a multidisciplinary …

G Pasello, D Scattolin, L Bonanno, F Caumo… - Cancer Treatment …, 2023 - Elsevier
Lung cancer (LC) is the leading cause of cancer-related death worldwide, mostly because
the lack of a screening program so far. Although smoking cessation has a central role in LC …

Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

J Shi, K Shiraishi, J Choi, K Matsuo, TY Chen… - Nature …, 2023 - nature.com
Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain
only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage …

Harnessing cancer genomes for precision oncology

SJ Chanock - Nature Genetics, 2024 - nature.com
Precision oncology has just received a boost: a report on the prevalence of mutations in
cancer driver genes based on whole genome sequencing of 10,000 clinical cases. The …

A systematic review of genetic ancestry as a risk factor for incidence of non-small cell lung cancer in the US

BA James, JL Williams, B Nemesure - Frontiers in Genetics, 2023 - frontiersin.org
Background: Non-Small Cell Lung Cancer (NSCLC), the leading cause of cancer-related
death in the United States, is the most diagnosed form of lung cancer. While lung cancer …

Advancing environmental epidemiologic methods to confront the cancer burden

RD Kehm, SE Lloyd, KR Burke… - American Journal of …, 2025 - academic.oup.com
Even though many environmental carcinogens have been identified, studying their effects
on specific cancers has been challenging in nonoccupational settings, where exposures …