To become resistant, cancer cells need to activate and maintain molecular defense
mechanisms that depend on an energy trade-off between resistance and essential functions …

Cancer chemoresistance is a problematic dilemma that significantly restrains numerous
cancer management protocols. It can promote cancer recurrence, spreading of cancer, and …

Phospholipase D (PLD) is a potential therapeutic target against cancer. However, the
contribution of PLD inhibition to the antitumor response remains unknown. We developed a …

The development of chemoresistance is a major challenge in the treatment of several types
of cancers in clinical settings. Stemness and chemoresistance are the chief causes of poor …

Abstract Background Small extrachromosomal circular DNAs (eccDNAs) have the potential
to be cancer biomarkers. However, the formation mechanisms and functions of small …

Glioblastoma (GBM) is a primary malignant brain tumor with a dismal prognosis, partially
due to our inability to completely remove and kill all GBM cells. Rapid tumor recurrence …

Squamous cell carcinomas (SCC) constitute a group of human malignancies that originate
from the squamous epithelium. Most patients with SCC experience treatment failure and …

Chaperone‑mediated autophagy (CMA) is a selec‑tive type of autophagy whereby a specific
subset of intracellular proteins is targeted to the lysosome for degradation. The present study …

Phospholipases D (PLDs) are important membrane lipid-modifying enzymes in eukaryotes.
Phosphatidic acid, the product of PLD activity, is a vital signaling molecule. PLD-mediated …

MicroRNAs (miRNAs) are small non-coding RNA molecules that play a role in cancer linked
to the regulation of important cellular processes and pathways involving tumorigenesis, cell …