Targeting janus kinases and signal transducer and activator of transcription 3 to treat inflammation, fibrosis, and cancer: rationale, progress, and caution
U Bharadwaj, MM Kasembeli, P Robinson… - Pharmacological …, 2020 - Elsevier
Before it was molecularly cloned in 1994, acute-phase response factor or signal transducer
and activator of transcription (STAT) 3 was the focus of intense research into understanding …
and activator of transcription (STAT) 3 was the focus of intense research into understanding …
Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases
M Cargnello, PP Roux - Microbiology and molecular biology …, 2011 - Am Soc Microbiol
The mitogen-activated protein kinases (MAPKs) regulate diverse cellular programs by
relaying extracellular signals to intracellular responses. In mammals, there are more than a …
relaying extracellular signals to intracellular responses. In mammals, there are more than a …
ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions
Conserved signaling pathways that activate the mitogen-activated protein kinases (MAPKs)
are involved in relaying extracellular stimulations to intracellular responses. The MAPKs …
are involved in relaying extracellular stimulations to intracellular responses. The MAPKs …
Uses for JNK: the many and varied substrates of the c-Jun N-terminal kinases
MA Bogoyevitch, B Kobe - Microbiology and Molecular Biology …, 2006 - Am Soc Microbiol
The c-Jun N-terminal kinases (JNKs) are members of a larger group of serine/threonine
(Ser/Thr) protein kinases from the mitogen-activated protein kinase family. JNKs were …
(Ser/Thr) protein kinases from the mitogen-activated protein kinase family. JNKs were …
Transcriptional regulation by the MAP kinase signaling cascades
SH Yang, AD Sharrocks, AJ Whitmarsh - Gene, 2003 - Elsevier
A major function of the mitogen-activated protein kinase (MAPK) pathways is to control
eukaryotic gene expression programmes in response to extracellular signals. MAPKs …
eukaryotic gene expression programmes in response to extracellular signals. MAPKs …
The role of mitogen-activated protein kinase-activated protein kinases (MAPKAPKs) in inflammation
U Moens, S Kostenko, B Sveinbjørnsson - Genes, 2013 - mdpi.com
Mitogen-activated protein kinase (MAPK) pathways are implicated in several cellular
processes including proliferation, differentiation, apoptosis, cell survival, cell motility …
processes including proliferation, differentiation, apoptosis, cell survival, cell motility …
Mitogen-activated protein kinase activation in UV-induced signal transduction
AM Bode, Z Dong - Science's STKE, 2003 - science.org
Experimental evidence supported by epidemiological findings suggests that solar ultraviolet
(UV) irradiation is the most important environmental carcinogen leading to the development …
(UV) irradiation is the most important environmental carcinogen leading to the development …
Regulation of the transcriptional activity of the nuclear factor-κB p65 subunit
L Vermeulen, G De Wilde, S Notebaert… - Biochemical …, 2002 - Elsevier
Nuclear factor-κB (NF-κB) is well known for its role in inflammation, immune response,
control of cell division and apoptosis. The function of NF-κB is primarily regulated by IκB …
control of cell division and apoptosis. The function of NF-κB is primarily regulated by IκB …
p38α mitogen-activated protein kinase sensitizes cells to apoptosis induced by different stimuli
p38α mitogen-activated protein (MAP) kinase is a broadly expressed signaling molecule that
participates in the regulation of cellular responses to stress as well as in the control of …
participates in the regulation of cellular responses to stress as well as in the control of …
The Ras-MAPK signal transduction pathway, cancer and chromatin remodeling
KL Dunn, PS Espino, B Drobic, S He… - Biochemistry and Cell …, 2005 - cdnsciencepub.com
La stimulation de la voie de transduction de signal Ras-MAPK (mitogen activated protein
kinase) résulte en une multitude d'événements incluant l'expression des gènes précoces …
kinase) résulte en une multitude d'événements incluant l'expression des gènes précoces …