The many faces of diabetes: a disease with increasing heterogeneity

T Tuomi, N Santoro, S Caprio, M Cai, J Weng, L Groop - The Lancet, 2014 - thelancet.com
Diabetes is a much more heterogeneous disease than the present subdivision into types 1
and 2 assumes; type 1 and type 2 diabetes probably represent extremes on a range of …

Adult-onset autoimmune diabetes: current knowledge and implications for management

R Buzzetti, S Zampetti, E Maddaloni - Nature Reviews Endocrinology, 2017 - nature.com
Adult-onset autoimmune diabetes is a heterogeneous disease that is characterized by a
reduced genetic load, a less intensive autoimmune process and a mild metabolic …

Cohort profile: the HUNT study, Norway

S Krokstad, A Langhammer, K Hveem… - International journal …, 2013 - academic.oup.com
The HUNT Study includes large total population-based cohorts from the 1980ies, covering
125 000 Norwegian participants; HUNT1 (1984-86), HUNT2 (1995-97) and HUNT3 (2006 …

Etiology and pathogenesis of latent autoimmune diabetes in adults (LADA) compared to type 2 diabetes

S Carlsson - Frontiers in physiology, 2019 - frontiersin.org
As the heterogeneity of diabetes is becoming increasingly clear, opportunities arise for more
accurate assessment of factors influencing disease onset, which may lead to more efficient …

Molecular mechanisms in autoimmune type 1 diabetes: a critical review

Z Xie, C Chang, Z Zhou - Clinical reviews in allergy & immunology, 2014 - Springer
Autoimmune type 1 diabetes is characterized by selective destruction of insulin-secreting
beta cells in the pancreas of genetically susceptible individuals. The mechanisms …

Genetic analysis of adult-onset autoimmune diabetes

JMM Howson, S Rosinger, DJ Smyth, BO Boehm… - Diabetes, 2011 - Am Diabetes Assoc
OBJECTIVE In contrast with childhood-onset type 1 diabetes, the genetics of autoimmune
diabetes in adults are not well understood. We have therefore investigated the genetics of …

Latent autoimmune diabetes in adults differs genetically from classical type 1 diabetes diagnosed after the age of 35 years

MK Andersen, V Lundgren, JA Turunen… - Diabetes …, 2010 - Am Diabetes Assoc
OBJECTIVE We studied differences between patients with latent autoimmune diabetes in
adults (LADA), type 2 diabetes, and classical type 1 diabetes diagnosed after age 35 years …

The type 2 diabetes-associated variant in TCF7L2 is associated with latent autoimmune diabetes in adult Europeans and the gene effect is modified by obesity: a …

K Lukács, N Hosszúfalusi, E Dinya, M Bakacs… - Diabetologia, 2012 - Springer
Aims/hypothesis The variants of transcription factor 7-like 2 (TCF7L2) gene have been
proposed to be associated with latent autoimmune diabetes in adults (LADA). We sought to …

HLA genetic discrepancy between latent autoimmune diabetes in adults and type 1 diabetes: LADA China Study No. 6

S Luo, J Lin, Z Xie, Y Xiang, P Zheng… - The Journal of …, 2016 - academic.oup.com
Context: The discrepancies in terms of human leukocyte antigen (HLA)-DRB1-DQA1-DQB1
conferred risks between latent autoimmune diabetes in adults (LADA) and type 1 diabetes …

Time dynamics of autoantibodies are coupled to phenotypes and add to the heterogeneity of autoimmune diabetes in adults: the HUNT study, Norway

EP Sørgjerd, F Skorpen, K Kvaløy, K Midthjell, V Grill - Diabetologia, 2012 - Springer
Aims The aetiology of latent autoimmune diabetes in adults (LADA), assessed by
autoimmune markers, is insufficiently clarified. We cross-sectionally investigated the …