[HTML][HTML] Mendelian randomization for studying the effects of perturbing drug targets
Drugs whose targets have genetic evidence to support efficacy and safety are more likely to
be approved after clinical development. In this paper, we provide an overview of how natural …
be approved after clinical development. In this paper, we provide an overview of how natural …
The UDP-glycosyltransferase (UGT) superfamily: new members, new functions, and novel paradigms
UDP-glycosyltransferases (UGTs) catalyze the covalent addition of sugars to a broad range
of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad …
of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad …
Using human genetics to understand the disease impacts of testosterone in men and women
Testosterone supplementation is commonly used for its effects on sexual function, bone
health and body composition, yet its effects on disease outcomes are unknown. To better …
health and body composition, yet its effects on disease outcomes are unknown. To better …
[HTML][HTML] The Rotterdam Study: 2018 update on objectives, design and main results
MA Ikram, GGO Brusselle, SD Murad… - European journal of …, 2017 - Springer
Abstract The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …
Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior
INTRODUCTION Across human societies and in both sexes, some 2 to 10% of individuals
report engaging in sex with same-sex partners, either exclusively or in addition to sex with …
report engaging in sex with same-sex partners, either exclusively or in addition to sex with …
A large electronic-health-record-based genome-wide study of serum lipids
TJ Hoffmann, E Theusch, T Haldar, DK Ranatunga… - Nature …, 2018 - nature.com
A genome-wide association study (GWAS) of 94,674 ancestrally diverse Kaiser Permanente
members using 478,866 longitudinal electronic health record (EHR)-derived measurements …
members using 478,866 longitudinal electronic health record (EHR)-derived measurements …
Using genetics to understand the causal influence of higher BMI on depression
Background Depression is more common in obese than non-obese individuals, especially in
women, but the causal relationship between obesity and depression is complex and …
women, but the causal relationship between obesity and depression is complex and …
GWAS of three molecular traits highlights core genes and pathways alongside a highly polygenic background
Genome-wide association studies (GWAS) have been used to study the genetic basis of a
wide variety of complex diseases and other traits. We describe UK Biobank GWAS results for …
wide variety of complex diseases and other traits. We describe UK Biobank GWAS results for …
Age-associated changes in hypothalamic–pituitary–testicular function in middle-aged and older men are modified by weight change and lifestyle factors: longitudinal …
EM Camacho, IT Huhtaniemi, TW O'neill… - European journal of …, 2013 - academic.oup.com
Objective Health and lifestyle factors are associated with variations in serum testosterone
levels in ageing men. However, it remains unclear how age-related changes in testosterone …
levels in ageing men. However, it remains unclear how age-related changes in testosterone …
Genetic evidence for a normal-weight “metabolically obese” phenotype linking insulin resistance, hypertension, coronary artery disease, and type 2 diabetes
The mechanisms that predispose to hypertension, coronary artery disease (CAD), and type
2 diabetes (T2D) in individuals of normal weight are poorly understood. In contrast, in …
2 diabetes (T2D) in individuals of normal weight are poorly understood. In contrast, in …