Elucidating the details of the formation, stability, interactions, and reactivity of biomolecular
systems under extreme environmental conditions, including high salt concentrations in …

The extent of the effect of cellular crowding and cosolutes on the functioning of proteins and
cells is manifold and includes the stabilization of the biomolecular systems, the excluded …

The dynamics of proteins in solution includes a variety of processes, such as backbone and
side-chain fluctuations, interdomain motions, as well as global rotational and translational …

Although nanoparticles (NPs) have been demonstrated as promising tools for improving oral
absorption of biotherapeutics, most of them still have very limited oral bioavailability. Lyso …

High hydrostatic pressure affects the structure, dynamics, and stability of biomolecular
systems and is a key parameter in the context of the exploration of the origin and the …

Background Molecular dynamics (MD) simulation is well-recognized as a powerful tool to
investigate protein structure, function, and thermodynamics. MD simulation is also used to …

Now that the centennial anniversary of the first report on pressure denaturation of proteins
by Nobel Laureate PW Bridgman can be celebrated, this Review on the application of high …

The scattering of neutrons can be used to provide information on the structure and dynamics
of biological systems on multiple length and time scales. Pursuant to a National Science …

Because organisms living in the deep sea and in the sub-seafloor must be able to cope with
hydrostatic pressures up to 1000 bar and more, their biomolecular processes, including …

Water and protein dynamics on a nanometer scale were measured by quasi-elastic neutron
scattering in the piezophile archaeon Thermococcus barophilus and the closely related …