Potential repurposed drug candidates for tuberculosis treatment: progress and update of drugs identified in over a decade

K Sharma, F Ahmed, T Sharma, A Grover… - ACS …, 2023 - ACS Publications
The devastating impact of Tuberculosis (TB) has been a menace to mankind for decades.
The World Health Organization (WHO) End TB Strategy aims to reduce TB mortality up to …

Repurposing high-throughput screening identifies unconventional drugs with antibacterial and antibiofilm activities against Pseudomonas aeruginosa under …

G Di Bonaventura, V Lupetti, A Di Giulio… - Microbiology …, 2023 - Am Soc Microbiol
Pseudomonas aeruginosa is the most common pathogen infecting cystic fibrosis (CF) lungs,
causing acute and chronic infections. Intrinsic and acquired antibiotic resistance allow P …

Ebselen: A Promising Repurposing Drug to Treat Infections Caused by Multidrug‐Resistant Microorganisms

A Alves de Lima e Silva… - … Perspectives on Infectious …, 2024 - Wiley Online Library
Bacterial multiresistance to drugs is a rapidly growing global phenomenon. New resistance
mechanisms have been described in different bacterial pathogens, threatening the effective …

Carbon dioxide regulates Mycobacterium tuberculosis PhoPR signaling and virulence

SJ Dechow, R Goyal, BK Johnson, RB Abramovitch - bioRxiv, 2022 - biorxiv.org
Abstract The Mycobacterium tuberculosis (Mtb) two-component regulatory system, PhoPR, is
implicated in pH-sensing within the macrophage because it is strongly induced by acidic pH …

Mycobacterium tuberculosis Growth Is Controlled Through the Coregulation of an Essential Response Regulator

D Giacalone - 2023 - search.proquest.com
Mycobacterium tuberculosis (Mtb), is the causative agent of tuberculosis (TB) and remains
one of the most deadly infectious diseases in the world. To survive within a host, Mtb must …