Orchestration of circadian timing by macromolecular protein assemblies
CL Partch - Journal of molecular biology, 2020 - Elsevier
Genetically encoded biological clocks are found broadly throughout eukaryotes and in
cyanobacteria, where they generate circadian (about a day) rhythms that allow organisms to …
cyanobacteria, where they generate circadian (about a day) rhythms that allow organisms to …
Periodicity, repression, and the molecular architecture of the mammalian circadian clock
C Rosensweig, CB Green - European Journal of Neuroscience, 2020 - Wiley Online Library
Large molecular machines regulate daily cycles of transcriptional activity and help generate
rhythmic behavior. In recent years, structural and biochemical analyses have elucidated a …
rhythmic behavior. In recent years, structural and biochemical analyses have elucidated a …
CLOCK regulates Drp1 mRNA stability and mitochondrial homeostasis by interacting with PUF60
L Xu, J Lin, Y Liu, B Hua, Q Cheng, C Lin, Z Yan… - Cell reports, 2022 - cell.com
Circadian genes such as Clock, Bmal1, Cryptochrome1/2, and Period1/2/3 constitute the
precise circadian system. Clock Δ19 is a commonly used mouse model harboring a …
precise circadian system. Clock Δ19 is a commonly used mouse model harboring a …
Clockwork orange promotes CLOCK-CYCLE activation via the putative Drosophila ortholog of clock interacting protein circadian
The Drosophila circadian clock is driven by a transcriptional feedback loop in which CLOCK-
CYCLE (CLK-CYC) binds E-boxes to transcribe genes encoding the PERIOD-TIMELESS …
CYCLE (CLK-CYC) binds E-boxes to transcribe genes encoding the PERIOD-TIMELESS …
TRITHORAX-dependent arginine methylation of HSP68 mediates circadian repression by PERIOD in the monarch butterfly
Transcriptional repression drives feedback loops that are central to the generation of
circadian (∼ 24-h) rhythms. In mammals, circadian repression of circadian locomotor output …
circadian (∼ 24-h) rhythms. In mammals, circadian repression of circadian locomotor output …
Circadian gene Clock regulates mitochondrial morphology and functions by posttranscriptional way
L Xu, Q Cheng, B Hua, T Cai, J Lin, G Yuan, Z Yan, X Li… - bioRxiv, 2018 - biorxiv.org
Many daily activities are under the control of circadian clock, including nutrition metabolism
and energy generation. Mitochondria, as the core factories of oxidizing substrates and …
and energy generation. Mitochondria, as the core factories of oxidizing substrates and …
Mutational scanning identified amino acids of the CLOCK exon 19‐domain essential for circadian rhythms
Aim In the mammalian circadian clock, the CLOCK/BMAL1 heterodimer binds to E‐box
enhancer elements in the promoters of its target genes to activate transcription. The classical …
enhancer elements in the promoters of its target genes to activate transcription. The classical …
A structural competition involving WDR5 times circadian oscillations
A Börgel, A Rawleigh, M Conrady, F Hof, K Ricci… - bioRxiv, 2023 - biorxiv.org
In the mammalian circadian clock, the transcription factor BMAL1/CLOCK cycles between an
active state recruiting co-activators like MLL1, and repressed states associated with the …
active state recruiting co-activators like MLL1, and repressed states associated with the …
Mutational scanning of CLOCK exon 19 transactivation domain
A Abdo - 2023 - refubium.fu-berlin.de
In zirkadianen Uhren von Säugetieren transaktiviert das CLOCK: BMAL1-Heterodimer E-
Box-Enhancer-Elemente, um die Transkription zirkadian exprimierter Zielgene zu …
Box-Enhancer-Elemente, um die Transkription zirkadian exprimierter Zielgene zu …
Examining prionogenic domains in the Swi1 protein, yeast evolution, and novel disease-related aggregators
DK Goncharoff - 2021 - search.proquest.com
Prions are self-perpetuating, alternative protein conformations associated with neurological
diseases and normal cellular functions. Saccharomyces cerevisiae contains many …
diseases and normal cellular functions. Saccharomyces cerevisiae contains many …