Homeostatic regulation of cardiomyocytes plays a crucial role in maintaining the normal
physiological activity of cardiac tissue. Severe cardiotoxicity results in cardiac diseases …

The myocardium is among the most energy-consuming tissues in the body, burning from 6 to
30 kg of ATP per day within the mitochondria, the so-called powerhouse of the …

Understanding individual susceptibility to drug-induced cardiotoxicity is key to improving
patient safety and preventing drug attrition. Human induced pluripotent stem cells (hiPSCs) …

Type 2 diabetes mellitus (T2DM) significantly impacts on human health and patient numbers
are predicted to rise. Discovering novel drugs and targets for treating T2DM is a research …

The ever-growing global burden of congestive heart failure (CHF) and type 2 diabetes
mellitus (T2DM) as well as their co-existence necessitate that anti-diabetic pharmacotherapy …

Background Cardiotoxicity remains one of the most reported adverse drug reactions that
lead to drug attrition during pre-clinical and clinical drug development. Drug-induced …

Thiazolidinediones (TZDs)(eg pioglitazone and rosiglitazone), known insulin sensitiser
agents for type II diabetes mellitus, exhibit controversial effects on cardiac tissue. Despite …

Hyperlipidemic pancreatitis (HP) is a serious inflammatory disease with very high mortality
and multiple organ injuries including renal injury. Rosiglitazone (Ros), an agonist of …

Radiation therapy (RT) is one of the main treatment modalities for cervical cancer.
Rosiglitazone (ROSI) has been reported to have antiproliferative effects against various …

Abstract Thiazolidinediones (TZDs), peroxisome proliferator-activated receptor gamma
(PPARγ) agonists, are highly effective antidiabetic drugs that are widely used to treat type 2 …