[HTML][HTML] Phytotherapy: A promising approach for the treatment of Alzheimer's disease

OO John, IS Amarachi, AP Chinazom, E Adaeze… - Pharmacological …, 2022 - Elsevier
Alzheimer's disease (AD) is a progressive neurological disease and the most common form
of dementia, affecting more than 10 million people all over the world. Clinically, AD is …

Neuroprotection by agmatine: Possible involvement of the gut microbiome?

P Saha, S Panda, A Holkar, R Vashishth… - Ageing Research …, 2023 - Elsevier
Agmatine, an endogenous polyamine derived from L-arginine, elicits tremendous
multimodal neuromodulant properties. Alterations in agmatinergic signalling are closely …

[HTML][HTML] Involvement of molecular chaperone in protein-misfolding brain diseases

NL Wankhede, MB Kale, AB Upaganlawar… - Biomedicine & …, 2022 - Elsevier
Protein misfolding causes aggregation and build-up in a variety of brain diseases. There are
numeral molecules that are linked with the protein homeostasis mechanism. Molecular …

Geniposide protects depression through BTK/JAK2/STAT1 signaling pathway in lipopolysaccharide-induced depressive mice

M Zheng, K Li, T Chen, S Liu, L He - Brain Research Bulletin, 2021 - Elsevier
The purpose of this study was to investigate the antidepressant mechanism of GEN
(geniposide) on depression mice induced by LPS. The mice were intragastrically treated …

Unraveling the nexus of age, epilepsy, and mitochondria: exploring the dynamics of cellular energy and excitability

W Xie, S Koppula, MB Kale, LS Ali… - Frontiers in …, 2024 - frontiersin.org
Epilepsy, a complex neurological condition marked by recurring seizures, is increasingly
recognized for its intricate relationship with mitochondria, the cellular powerhouses …

Prenatal alcohol and tetrahydrocannabinol exposure: Effects on spatial and working memory

A Lei, KR Breit, JD Thomas - Frontiers in Neuroscience, 2023 - frontiersin.org
Introduction Alcohol and cannabis are widely used recreational drugs that can negatively
impact fetal development, leading to cognitive impairments. However, these drugs may be …

Psychopharmacological treatments in children with fetal alcohol spectrum disorders: a review

GJ Ritfeld, JA Kable, JE Holton, CD Coles - Child Psychiatry & Human …, 2022 - Springer
Psychiatric symptoms in children with Fetal Alcohol Spectrum Disorders (FASD) present with
high prevalence and morbidity, often across symptom domains, eg ADHD-like symptoms …

Possible involvement of agmatine in neuropharmacological actions of metformin in diabetic mice

N Kotagale, S Rahangdale, A Borkar, K Singh… - European journal of …, 2021 - Elsevier
The risk of psychiatric and neurological disorders is significantly higher in patients with
diabetes mellitus. Diabetic patients are more susceptible to depression, anxiety and memory …

Administration of agmatine prior to physical or psychological stress in pregnant mice ameliorates behavioural and cognitive deficits in female offspring

A Hassanshahi, M Janahmadi… - International Journal …, 2023 - Wiley Online Library
Physical or psychological stress experienced by a mother during gestation is often
associated with serious behavioural and cognitive deficits in newborns. Investigations of …

Agmatine diminishes behavioral and endocrine alterations in a rat model of post-traumatic stress disorder

MB Kale, SR Rahangdale, TA Banarase… - Neuroscience …, 2025 - Elsevier
Post-traumatic stress disorder (PTSD), is a severe anxiety disorder characterized by
associative fear conditioning. Single prolonged stress (SPS) is a widely accepted reliable …