Abstract Cancer-associated fibroblasts (CAFs), enriched in the tumor stroma, have received
increasing attention because of their multifaceted effects on tumorigenesis, development …

Simple Summary In the last 20 years, the tumor microenvironment (TME) has raised an
increasing interest from the therapeutic point of view. Indeed, different strategies targeting …

Breast cancer is a heterogeneous disease with variable survival outcomes. Pathologists
grade the microscopic appearance of breast tissue using the Nottingham criteria, which are …

Background Colorectal cancer (CRC) consensus molecular subtypes (CMS) have different
immunological, stromal cell, and clinicopathological characteristics. Single-cell …

Precancerous lesions of the oral mucosa, especially those accompanied by moderate to
severe dysplasia, contribute to the initiation of oral squamous cell carcinoma (OSCC) …

The tumor stroma of pancreatic ductal adenocarcinoma (PDAC) is characterized by an
abundant and heterogeneous population of cancer-associated fibroblasts (CAFs), which are …

Background Cancer-associated fibroblasts (CAFs) are a vital constituent of the tumor
microenvironment (TME) and have several activities, but the effect of CAF heterogeneity on …

During cancer progression, tumorigenic and immune signals are spread through circulating
molecules, such as cell-free DNA (cfDNA) and cell-free RNA (cfRNA) in the blood. So far …

Immune checkpoint inhibitors (ICI) represent the cornerstone for the treatment of patients
with metastatic clear cell renal cell carcinoma (ccRCC). Despite a favorable response for a …

Convolutional neural networks (CNNs) are deep learning models used widely for solving
various tasks like computer vision and speech recognition. CNNs are developed manually …