A review of emerging technologies enabling improved solid oral dosage form manufacturing and processing
Tablets are the most widely utilized solid oral dosage forms because of the advantages of
self-administration, stability, ease of handling, transportation, and good patient compliance …
self-administration, stability, ease of handling, transportation, and good patient compliance …
Pharmaceutical cocrystallization techniques. Advances and challenges
M Rodrigues, B Baptista, JA Lopes… - International Journal of …, 2018 - Elsevier
Cocrystals are homogenous (single-phase) crystalline structures composed by two or more
components in a definite stoichiometric ratio bonded together by noncovalent bonds …
components in a definite stoichiometric ratio bonded together by noncovalent bonds …
Integrated continuous pharmaceutical technologies—a review
Innovation in the pharmaceutical industry has been limited for a long time to the research
and development of new active compounds; meanwhile, the structure of the production …
and development of new active compounds; meanwhile, the structure of the production …
3D printed oral solid dosage form: Modified release and improved solubility
N Wang, H Shi, S Yang - Journal of Controlled Release, 2022 - Elsevier
Oral solid dosage form is currently the most common used form of drug. 3D Printing, also
known as additive manufacturing (AM), can quickly print customized and individualized oral …
known as additive manufacturing (AM), can quickly print customized and individualized oral …
Blend segregation in tablets manufacturing and its effect on drug content uniformity—A review
E Jakubowska, N Ciepluch - Pharmaceutics, 2021 - mdpi.com
Content uniformity (CU) of the active pharmaceutical ingredient is a critical quality attribute of
tablets as a dosage form, ensuring reproducible drug potency. Failure to meet the accepted …
tablets as a dosage form, ensuring reproducible drug potency. Failure to meet the accepted …
In-line Raman spectroscopic monitoring and feedback control of a continuous twin-screw pharmaceutical powder blending and tableting process
Abstract The integration of Process Analytical Technology (PAT) initiative into the continuous
production of pharmaceuticals is indispensable for reliable production. The present paper …
production of pharmaceuticals is indispensable for reliable production. The present paper …
[HTML][HTML] End-to-end continuous manufacturing of conventional compressed tablets: From flow synthesis to tableting through integrated crystallization and filtration
An end-to-end continuous pharmaceutical manufacturing process was developed for the
production of conventional direct compressed tablets on a proof-of-concept level for the first …
production of conventional direct compressed tablets on a proof-of-concept level for the first …
Achieving continuous manufacturing in lyophilization: Technologies and approaches
This paper provides an organic overview of the most interesting continuous freeze-drying
concepts that have been proposed over the years. Attention has mainly been focused on the …
concepts that have been proposed over the years. Attention has mainly been focused on the …
From batch to continuous: freeze-drying of suspended vials for pharmaceuticals in unit-doses
LC Capozzi, BL Trout, R Pisano - Industrial & Engineering …, 2019 - ACS Publications
In response to the current trend in the pharmaceutical industry, a new concept for the freeze-
drying of pharmaceuticals in unit-doses is presented: the continuous freeze …
drying of pharmaceuticals in unit-doses is presented: the continuous freeze …
Twin screw melt granulation: a single step approach for developing self-emulsifying drug delivery system for lipophilic drugs
The current research aims to improve the solubility of the poorly soluble drug, ie, ibuprofen,
by developing self-emulsifying drug delivery systems (SEDDS) utilizing a twin screw melt …
by developing self-emulsifying drug delivery systems (SEDDS) utilizing a twin screw melt …