Hepeviridae: an expanding family of vertebrate viruses

R Johne, P Dremsek, J Reetz, G Heckel, M Hess… - Infection, Genetics and …, 2014 - Elsevier
The hepatitis E virus (HEV) was first identified in 1990, although hepatitis E-like diseases in
humans have been recorded for a long time dating back to the 18th century. The HEV …

Molecular biology and infection of hepatitis E virus

Y Nan, YJ Zhang - Frontiers in microbiology, 2016 - frontiersin.org
Hepatitis E virus (HEV) is a viral pathogen transmitted primarily via fecal-oral route. In
humans, HEV mainly causes acute hepatitis and is responsible for large outbreaks of …

Hepatitis E virus ORF3 is a functional ion channel required for release of infectious particles

Q Ding, B Heller, JMV Capuccino… - Proceedings of the …, 2017 - National Acad Sciences
Hepatitis E virus (HEV) is the leading cause of enterically transmitted viral hepatitis globally.
Of HEV's three ORFs, the function of ORF3 has remained elusive. Here, we demonstrate that …

Human liver chimeric mice as a new model of chronic hepatitis E virus infection and preclinical drug evaluation

L Allweiss, S Gass, K Giersch, A Groth, J Kah, T Volz… - Journal of …, 2016 - Elsevier
Background & Aims Hepatitis E virus (HEV) is a major cause of acute hepatitis as well as
chronic infection in immunocompromised individuals; however, in vivo infection models are …

Hepatitis E virus infections in Europe

J Izopet, P Tremeaux, O Marion, M Migueres… - Journal of Clinical …, 2019 - Elsevier
Hepatitis E virus (HEV) is the most common cause of acute viral hepatitis worldwide. The
systematic use of improved tools for diagnosing and genotyping has completely changed …

Palmitoylation mediates membrane association of hepatitis E virus ORF3 protein and is required for infectious particle secretion

J Gouttenoire, A Pollan, L Abrami, N Oechslin… - PLoS …, 2018 - journals.plos.org
Hepatitis E virus (HEV) is a positive-strand RNA virus encoding 3 open reading frames
(ORF). HEV ORF3 protein is a small, hitherto poorly characterized protein involved in viral …

Molecular virology of hepatitis E virus

RP Holla, I Ahmad, Z Ahmad… - Seminars in liver …, 2013 - thieme-connect.com
Hepatitis E virus (HEV) is the causative agent of hepatitis E. It is a nonenveloped virus with
a∼ 7.2 kilobases positive-stranded RNA genome. The molecular virology of HEV is getting …

Life cycle and morphogenesis of the hepatitis E virus

K Himmelsbach, D Bender, E Hildt - Emerging microbes & …, 2018 - Taylor & Francis
Hepatitis E virus (HEV) is transmitted primarily via contaminated water and food by the fecal
oral route and causes epidemics in developing countries. In industrialized countries …

Role of envelopment in the HEV life cycle

X Yin, X Li, Z Feng - Viruses, 2016 - mdpi.com
Hepatitis E virus (HEV), an enterically transmitted hepatotropic virus, was thought to be non-
enveloped for decades. However, recent studies have revealed that the virus circulating in …

Recombinant hepatitis E viruses harboring tags in the ORF1 protein

D Szkolnicka, A Pollán, N Da Silva, N Oechslin… - Journal of …, 2019 - Am Soc Microbiol
Hepatitis E virus (HEV) is one of the most common causes of acute hepatitis and jaundice in
the world. Current understanding of the molecular virology and pathogenesis of hepatitis E …