The naked truth: a comprehensive clarification and classification of current 'myths' in naked mole‐rat biology

R Buffenstein, V Amoroso, B Andziak… - Biological …, 2022 - Wiley Online Library
The naked mole‐rat (Heterocephalus glaber) has fascinated zoologists for at least half a
century. It has also generated considerable biomedical interest not only because of its …

[HTML][HTML] Local diffusion in the extracellular space of the brain

J Tønnesen, S Hrabĕtová, FN Soria - Neurobiology of Disease, 2023 - Elsevier
The brain extracellular space (ECS) is a vast interstitial reticulum of extreme morphological
complexity, composed of narrow gaps separated by local expansions, enabling …

The role of senescence in cancer development

E Mavrogonatou, H Pratsinis, D Kletsas - Seminars in cancer biology, 2020 - Elsevier
While research on cancer development is traditionally focusing mainly on the neoplastic cell
per se, nowadays the role of tumor stroma in this process is indisputable. The stroma-mainly …

Surprisingly long survival of premature conclusions about naked mole‐rat biology

S Braude, S Holtze, S Begall, J Brenmoehl… - Biological …, 2021 - Wiley Online Library
Naked mole‐rats express many unusual traits for such a small rodent. Their morphology,
social behaviour, physiology, and ageing have been well studied over the past half‐century …

Transformation of naked mole-rat cells

F Hadi, Y Kulaberoglu, KA Lazarus, K Bach, R Ugur… - Nature, 2020 - nature.com
The naked mole rat (NMR), Heterocephalus glaber, is a mouse-sized subterranean rodent
that is native to East Africa and is used in research for the potential development of …

Matters of size: Roles of hyaluronan in CNS aging and disease

FT Zakusilo, MK O'Banion, HA Gelbard… - Ageing research …, 2021 - Elsevier
Involvement of extracellular matrix (ECM) components in aging and age-related
neurodegeneration is not well understood. The role of hyaluronan (HA), a major …

Naked mole-rat hyaluronan

FA Lagunas-Rangel - Biochimie, 2024 - Elsevier
Naked mole rats (NMRs) are renowned for their exceptional longevity and remarkable
maintenance of health throughout their lifetime. Their subterranean lifestyle has led to …

Naked mole-rats: resistant to developing cancer or good at avoiding it?

F Hadi, ESJ Smith, WT Khaled - The extraordinary biology of the naked …, 2021 - Springer
It is widely accepted that cancer is driven by genetic mutations that confer uncontrolled cell
proliferation and tumor formation. For tumors to take hold and grow, cancer cells evolve …

Skin aging in long-lived naked mole-rats is accompanied by increased expression of longevity-associated and tumor suppressor genes

I Fatima, G Chen, NV Botchkareva, AA Sharov… - Journal of Investigative …, 2022 - Elsevier
Naked mole-rats (NMRs)(Heterocephalus glaber) are long-lived mammals that possess a
natural resistance to cancer and other age-related pathologies, maintaining a healthy life …

Abundance and size of hyaluronan in naked mole-rat tissues and plasma

D Del Marmol, S Holtze, N Kichler, A Sahm, B Bihin… - Scientific reports, 2021 - nature.com
Large amounts of ultra-high molecular weight hyaluronan (HA) have been described as the
main cause of cancer resistance in naked mole-rats (Heterocephalus glaber, NMR). Our …