Connective tissue growth factor, also known as CCN2, is a cysteine-rich matricellular protein
involved in the control of biological processes, such as cell proliferation, differentiation …

Systemic sclerosis is a complex autoimmune disease characterized by a chronic and
frequently progressive course and by extensive patient-to-patient variability. Like other …

Transforming growth factor β (TGFβ) pathways are implicated in metazoan development,
adult homeostasis and disease. TGFβ ligands signal via receptor serine/threonine kinases …

Members of the CCN (CYR61/CTGF/NOV) family have emerged as dynamically expressed,
extracellular matrix-associated proteins that play critical roles in cardiovascular and skeletal …

The CCN family is a group of six secreted proteins that specifically associate with the
extracellular matrix. Structurally, CCN proteins are modular, containing up to four distinct …

Connective tissue growth factor (CTGF, CCN2) is a secreted protein with major roles in
angiogenesis, chondrogenesis, osteogenesis, tissue repair, cancer and fibrosis. It is a …

CTGF is upregulated in patients with idiopathic pulmonary fibrosis (IPF), characterized by
the deposition of a pathological extracellular matrix (ECM). Additionally, many omics studies …

The cytokine transforming growth factor β (TGFβ) is a major contributor to fibrogenic
responses both in vitro and in vivo. TGFβ possesses many functions; thus, broadly targeting …

Dupuytren disease is a fibrotic disorder characterized by contraction of myofibroblast-rich
cords and nodules in the hands. The Hippo member Yes-associated protein 1 (YAP1) is …

Connective tissue growth factor (CTGF), a multifunctional protein of the CCN family,
regulates cell proliferation, differentiation, adhesion, and a variety of other biological …