Since ancient times it is known that melancholia and sleep disturbances co-occur. The
introduction of polysomnography into psychiatric research confirmed a disturbance of sleep …

Orexins (hypocretins) are two peptides (orexin A and B) produced from the pre-pro-orexin
precursor and expressed in a limited region of dorsolateral hypothalamus. Orexins were …

One decade ago, our laboratory provided the first direct evidence linking orexin/hypocretin
signaling with drug seeking by showing that activation of these neurons promotes …

Mood disorders are amongst the most prevalent and severe disorders worldwide, with a
tendency to be recurrent and disabling. Although multiple mechanisms have been …

Insomnia disorder is considered as a stress‐related disorder associated with hyperarousal,
stress and emotion dysregulation and the instability of the 'flip‐flop'switch system. The …

Orexin is a neurotransmitter produced by a small group of hypothalamic neurons. Besides its
well-known role in the regulation of the sleep-wake cycle, the orexin system was shown to …

Orexins comprise two neuropeptides produced by orexin neurons in the lateral
hypothalamus and are released by extensive projections of these neurons throughout the …

Orexins (hypocretins) are critically involved in coordinating appropriate physiological and
behavioral responses to aversive and threatening stimuli. Acute stressors engage orexin …

Background Seltorexant, a selective antagonist of human orexin-2 receptors, demonstrated
antidepressant effects in a previous exploratory study in patients with major depressive …

The orexin (also known as hypocretin) system, consisting of neuropeptides orexin‐A and
orexin‐B, was discovered over 25 years ago and was immediately identified as a central …